NP_758957.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,774 Da
NCBI Official Full Name
complement C1q subcomponent subunit C
NCBI Official Synonym Full Names
complement component 1, q subcomponent, C chain
NCBI Official Synonym Symbols
NCBI Protein Information
complement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide
UniProt Protein Name
Complement C1q subcomponent subunit C
UniProt Synonym Gene Names
UniProt Entry Name
C1QC_HUMAN
NCBI Summary for C1q
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for C1q
C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: extracellular space; collagen; extracellular region
Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; negative regulation of granulocyte differentiation; complement activation
Disease: C1q Deficiency
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Products associated with C1q elisa kit
Pathways associated with C1q elisa kit
Diseases associated with C1q elisa kit
Organs/Tissues associated with C1q elisa kit
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