Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow BLNK rightarrow Mouse BLNK  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Diacylglycerol-O-Acyltransf erase Homolog 1 (DGAT1) ELISA Kit
 • Crk-like protein (CRKL) ELISA Kit
 • ZKSCAN3 Antibody
 • 30S ribosomal protein S2 (rpsB) Antibody
 • 3-hydroxybutyrate dehydrogenase, type 1 (BDH1) ELISA Kit
 • HSD17B3 Antibody
 • Glutathione S Transferase Alpha 4 (GSTa4) Antibody
 • AQP2 Blocking Peptide
 • Augmenter of Liver Regeneration (ALR) ELISA Kit
 • Cyclin D1 (CCND1) Antibody
 • CD49d Antibody
 • Interferon Gamma (IFNg) ELISA Kit
 • ACTA2 Recombinant Protein
 • Olfactory Lobe Tissue Lysate Native Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

BLNK elisa kit :: Mouse B-Cell Linker Protein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS731574 BLNK elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-Cell Linker Protein (BLNK), ELISA Kit

 Also Known As   

Mouse B-Cell Linker Protein ELISA Kit

 Product Gene Name   

BLNK elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Request for Manual Insert    Request Manual
 OMIM    gene 613502
Section Bar
 Species Reactivity    Mouse
Section Bar
Section Bar
 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact technical support.
 Other Notes    Small volumes of BLNK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BLNK purchase    MBS731574 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B-Cell Linker Protein (BLNK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards render a theoretical kit detection range in biological research samples containing BLNK. The ELISA analytical biochemical technique of the MBS731574 kit is based on BLNK antibody-BLNK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BLNK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BLNK. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
 Product Categories/Family for BLNK elisa kit    Cell Biology
NCBI/Uniprot data below describe general gene information for BLNK. It may not necessarily be applicable to this product.
 NCBI GI #    166235901
 NCBI GeneID    29760
 NCBI Accession #    NP_001107566.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114094.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    O75498; O75499; Q2MD49 [Other Products]
 UniProt Related Accession #    Q8WV28 [Other Products]
 Molecular Weight    44,451 Da
Table BarTOPTable Bar
 NCBI Official Full Name    B-cell linker protein isoform 2
 NCBI Official Synonym Full Names    B-cell linker
 NCBI Official Symbol    BLNK [Similar Products]
 NCBI Official Synonym Symbols   
bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65
[Similar Products]
 NCBI Protein Information    B-cell linker protein; B-cell activation; B cell linker protein; cytoplasmic adapter protein; B cell adaptor containing SH2 domain; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Src homology 2 domain-containing leukocyte protein of 65 kDa
 UniProt Protein Name    B-cell linker protein
 UniProt Synonym Protein Names   
B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65
 Protein Family    B-cell linker protein
 UniProt Gene Name    BLNK [Similar Products]
 UniProt Synonym Gene Names    BASH; SLP65; SLP-65 [Similar Products]
 UniProt Entry Name    BLNK_HUMAN
Section Bar
 NCBI Summary for BLNK    This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Section Bar
 UniProt Comments for BLNK    BLNK: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23.2-q23.33

Cellular Component: plasma membrane; intracellular; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: positive regulation of signal transduction; B cell differentiation; inflammatory response; humoral immune response; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Agammaglobulinemia 4, Autosomal Recessive
Table BarTOPTable Bar
 Research Articles on BLNK    1. early Ca(2+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 C2 domain to phospho-SLP65.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products related to Mouse B-Cell Linker Protein ELISA Kit
 Catalog #  Product Name  Catalog #  Product Name
 MBS264749  Rat B-Cell Linker Protein (BLNK) ELISA Kit  MBS746461  Sheep B-Cell Linker Protein ELISA Kit
 MBS2608466  Canine B-Cell Linker Protein (BLNK) ELISA Kit  MBS045742  Rabbit B-Cell Linker Protein ELISA Kit
 MBS731574  Mouse B-Cell Linker Protein ELISA Kit  MBS096899  Donkey B-Cell Linker Protein ELISA Kit
 MBS745378  Canine B-Cell Linker Protein ELISA Kit  MBS728929  Guinea pig B-Cell Linker Protein ELISA Kit
 MBS2881714  Human B-cell linker protein ELISA Kit  MBS288562  Rat B-cell linker protein ELISA Kit
Products associated with BLNK elisa kitPathways associated with BLNK elisa kit
 Reference Product  PubMed Publications
 SYK elisa kit  >72 publications with BLNK and SYK
 BTK elisa kit  >39 publications with BLNK and BTK
 CD79A elisa kit  >11 publications with BLNK and CD79A
 GRB2 elisa kit  >9 publications with BLNK and GRB2
 PTPN6 elisa kit  >4 publications with BLNK and PTPN6
 SH3KBP1 elisa kit  >3 publications with BLNK and SH3KBP1
 PLCG2 elisa kit  >2 publications with BLNK and PLCG2
 VAV1 elisa kit  >2 publications with BLNK and VAV1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-3, 5 And GM-CSF Signaling Pathway antibodies  Interleukin-3, 5 And GM-CSF Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
Diseases associated with BLNK elisa kitOrgans/Tissues associated with BLNK elisa kit
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with BLNK and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >4 publications with BLNK and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >2 publications with BLNK and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with BLNK and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >2 publications with BLNK and Cell Transformation, Neoplastic
 Necrosis Antibodies  >2 publications with BLNK and Necrosis
 Inflammation Antibodies  >2 publications with BLNK and Inflammation
 Precancerous Conditions Antibodies  >1 publications with BLNK and Precancerous Conditions
 Liver Diseases Antibodies  >1 publications with BLNK and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with BLNK and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >114 publications with BLNK and Blood
 Spleen Antibodies  >19 publications with BLNK and Spleen
 Lung Antibodies  >4 publications with BLNK and Lung
 Lymph Antibodies  >3 publications with BLNK and Lymph
 Connective Tissue Antibodies  >3 publications with BLNK and Connective Tissue
 Lymph Node Antibodies  >3 publications with BLNK and Lymph Node
 Uterus Antibodies  >1 publications with BLNK and Uterus
 Placenta Antibodies  >1 publications with BLNK and Placenta
 Brain Antibodies  >1 publications with BLNK and Brain
 Parathyroid Antibodies  >1 publications with BLNK and Parathyroid
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions