NP_001179.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,872 Da
NCBI Official Full Name
bcl-2 homologous antagonist/killer
NCBI Official Synonym Full Names
BCL2-antagonist/killer 1
NCBI Protein Information
bcl-2 homologous antagonist/killer; BCL2-like 7 protein; apoptosis regulator BAK; bcl-2-like protein 7; bcl2-L-7; pro-apoptotic protein BAK
UniProt Protein Name
Bcl-2 homologous antagonist/killer
UniProt Synonym Protein Names
Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7
UniProt Synonym Gene Names
UniProt Entry Name
BAK_HUMAN
NCBI Summary for BAK1
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
UniProt Comments for BAK1
BAK1: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Interacts with BCL2A1. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Belongs to the Bcl-2 family.
Protein type: Endoplasmic reticulum; Apoptosis; Mitochondrial; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; cytosol; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity; chaperone binding; metal ion binding; heat shock protein binding
Biological Process: response to fungus; regulation of protein heterodimerization activity; positive regulation of proteolysis; apoptosis; positive regulation of apoptosis; regulation of cell cycle; myeloid cell homeostasis; negative regulation of peptidyl-serine phosphorylation; B cell apoptosis; response to organic cyclic substance; negative regulation of cell proliferation; B cell homeostasis; regulation of mitochondrial membrane potential; response to gamma radiation; establishment and/or maintenance of transmembrane electrochemical gradient; B cell negative selection; aging; response to drug; release of cytochrome c from mitochondria; organ regeneration; response to mycotoxin; mitochondrial fusion; regulation of protein homodimerization activity; vagina development; endocrine pancreas development; limb morphogenesis; response to UV-C; cell proliferation; endoplasmic reticulum calcium ion homeostasis; unfolded protein response, activation of signaling protein activity; response to ethanol; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; reduction of endoplasmic reticulum calcium ion concentration; blood vessel remodeling; caspase activation via cytochrome c; regulation of mitochondrial membrane permeability; brain development; post-embryonic camera-type eye morphogenesis
Research Articles on BAK1
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Products associated with BAK1 elisa kit
Pathways associated with BAK1 elisa kit
Diseases associated with BAK1 elisa kit
Organs/Tissues associated with BAK1 elisa kit
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