NP_033885.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
111,666 Da
NCBI Official Full Name
bone morphogenetic protein 1
NCBI Official Synonym Full Names
bone morphogenetic protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
bone morphogenetic protein 1
UniProt Protein Name
Bone morphogenetic protein 1
UniProt Synonym Protein Names
Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP
UniProt Synonym Gene Names
UniProt Entry Name
BMP1_MOUSE
NCBI Summary for BMP1
This gene encodes a metalloproteinase that plays an essential role in the formation of the extracellular matrix and is also able to induce ectopic bone formation. Unlike other bone morphogenetic proteins, the protein encoded by this gene is not closely related to transforming growth factor-beta. This protein plays in role several developmental processes. In humans, mutations in this gene are associated with osteogenesis imperfecta and with increased bone mineral density and multiple recurrent fractures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Comments for BMP1
BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Cytokine; EC 3.4.24.19
Cellular Component: Golgi apparatus; extracellular space; proteinaceous extracellular matrix; extracellular region
Molecular Function: peptidase activity; protein binding; growth factor activity; zinc ion binding; hydrolase activity; metallopeptidase activity; metalloendopeptidase activity; metal ion binding; cytokine activity; calcium ion binding
Biological Process: ossification; cartilage development; multicellular organismal development; proteolysis; cell differentiation
Research Articles on BMP1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with BMP1 elisa kit
Diseases associated with BMP1 elisa kit
Organs/Tissues associated with BMP1 elisa kit
|