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BMP-4 elisa kit :: Mouse Bone Morphogenetic Protein 4 (BMP-4) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS260174
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $275 +1 FREE 8GB USB
96-Strip-Wells  /  $435 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,755 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,150 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Morphogenetic Protein 4 (BMP-4), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Bone Morphogenetic Protein 4 (BMP-4) ELISA Kit

 Product Gene Name   

BMP-4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    607932
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 Species Reactivity    Mouse
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 Specificity    No cross-reaction with other factors.
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 Samples    Mouse serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant BMP-4 concentration
 Assay Type    Sandwich
 Detection Range    10 ng/ml-0.156 ng/ml
 Sensitivity    0.05 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BMP-4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BMP-4 purchase    MBS260174 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bone Morphogenetic Protein 4 (BMP-4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10 ng/ml-0.156 ng/ml in biological research samples containing BMP-4, with an estimated sensitivity of 0.05 ng/ml. The ELISA analytical biochemical technique of the MBS260174 kit is based on BMP-4 antibody-BMP-4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BMP-4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BMP-4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Mouse serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant BMP-4 concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for BMP-4 elisa kit

   Principle of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Mouse BMP-4 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of BMP-4 elisa kit    BMP-4 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS260174. Click to request current manual
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NCBI/Uniprot data below describe general gene information for BMP-4. It may not necessarily be applicable to this product.
 NCBI GI #    1311542
 NCBI GeneID    652
 NCBI Accession #    BAA06410.1 [Other Products]
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 UniProt Secondary Accession #    Q9UM80 [Other Products]
 UniProt Related Accession #    P12644 [Other Products]
 Molecular Weight    46,555 Da
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 NCBI Official Full Name    bone morphogenetic protein 4
 NCBI Official Synonym Full Names    bone morphogenetic protein 4
 NCBI Official Symbol    BMP4 [Similar Products]
 NCBI Official Synonym Symbols   
ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 4; BMP-4; BMP-2B; bone morphogenetic protein 2B
 UniProt Protein Name    Bone morphogenetic protein 4
 UniProt Synonym Protein Names   
Bone morphogenetic protein 2B; BMP-2B
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP4 [Similar Products]
 UniProt Synonym Gene Names    BMP2B; DVR4; BMP-4; BMP-2B [Similar Products]
 UniProt Entry Name    BMP4_HUMAN
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 NCBI Summary for BMP-4    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP-4    BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q22-q23

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; chemoattractant activity

Biological Process: negative regulation of MAP kinase activity; extracellular matrix organization and biogenesis; renal system process; macrophage differentiation; activation of MAPKK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; lymphoid progenitor cell differentiation; telencephalon regionalization; post-embryonic development; germ cell development; BMP signaling pathway; regulation of protein import into nucleus; positive regulation of endothelial cell differentiation; positive chemotaxis; chondrocyte differentiation; erythrocyte differentiation; mesonephros development; kidney development; regulation of odontogenesis of dentine-containing teeth; endochondral ossification; negative regulation of immature T cell proliferation in the thymus; positive regulation of cardiac muscle fiber development; specification of organ position; monocyte differentiation; neuron fate commitment; embryonic cranial skeleton morphogenesis; negative regulation of striated muscle development; branching morphogenesis of a tube; negative regulation of mitosis; positive regulation of epidermal cell differentiation; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; positive regulation of endothelial cell proliferation; steroid hormone mediated signaling; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; cloacal septation; positive regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; negative regulation of cell cycle; odontogenesis; smooth muscle development; negative regulation of cell proliferation; inner ear receptor cell differentiation; ureteric bud development; intermediate mesodermal cell differentiation; regulation of smooth muscle cell differentiation; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of epithelial cell proliferation; smoothened signaling pathway; common-partner SMAD protein phosphorylation; negative regulation of T cell differentiation in the thymus; positive regulation of bone mineralization; positive regulation of ossification; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of osteoblast differentiation; telencephalon development; blood vessel endothelial cell proliferation during sprouting angiogenesis; ureteric bud branching; pituitary gland development; regulation of cell fate commitment; neural tube closure; positive regulation of protein amino acid phosphorylation; positive regulation of neuron differentiation; negative regulation of myoblast differentiation; mesodermal cell fate determination; anterior/posterior axis specification

Disease: Orofacial Cleft 11; Microphthalmia, Syndromic 6
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 Research Articles on BMP-4    1. BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP-4 elisa kitPathways associated with BMP-4 elisa kit
 Reference Product  PubMed Publications
 SHH elisa kit  >233 publications with BMP-4 and SHH
 BMPR2 elisa kit  >135 publications with BMP-4 and BMPR2
 BMPR1A elisa kit  >134 publications with BMP-4 and BMPR1A
 SMAD5 elisa kit  >73 publications with BMP-4 and SMAD5
 BMPR1B elisa kit  >31 publications with BMP-4 and BMPR1B
 NOG elisa kit  >17 publications with BMP-4 and NOG
 SOSTDC1 elisa kit  >6 publications with BMP-4 and SOSTDC1
 FST elisa kit  >4 publications with BMP-4 and FST
 CHRD elisa kit  >4 publications with BMP-4 and CHRD
 CHRDL1 elisa kit  >3 publications with BMP-4 and CHRDL1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
Diseases associated with BMP-4 elisa kitOrgans/Tissues associated with BMP-4 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >216 publications with BMP-4 and Neoplasms
 Disease Models, Animal Antibodies  >96 publications with BMP-4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >93 publications with BMP-4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >89 publications with BMP-4 and Nervous System Diseases
 Heart Diseases Antibodies  >54 publications with BMP-4 and Heart Diseases
 Inflammation Antibodies  >51 publications with BMP-4 and Inflammation
 Hypertension Antibodies  >50 publications with BMP-4 and Hypertension
 Brain Diseases Antibodies  >49 publications with BMP-4 and Brain Diseases
 Adenocarcinoma Antibodies  >45 publications with BMP-4 and Adenocarcinoma
 Lung Diseases Antibodies  >41 publications with BMP-4 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2408 publications with BMP-4 and Bone
 Embryonic Tissue Antibodies  >648 publications with BMP-4 and Embryonic Tissue
 Brain Antibodies  >246 publications with BMP-4 and Brain
 Vascular Antibodies  >222 publications with BMP-4 and Vascular
 Heart Antibodies  >200 publications with BMP-4 and Heart
 Mouth Antibodies  >163 publications with BMP-4 and Mouth
 Connective Tissue Antibodies  >162 publications with BMP-4 and Connective Tissue
 Eye Antibodies  >148 publications with BMP-4 and Eye
 Lung Antibodies  >119 publications with BMP-4 and Lung
 Skin Antibodies  >118 publications with BMP-4 and Skin
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