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ZMPSTE24 elisa kit :: Mouse CAAX prenyl protease 1 homolog (ZMPSTE24) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7229246 ZMPSTE24 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CAAX prenyl protease 1 homolog (ZMPSTE24), ELISA Kit

 Also Known As   

Mouse CAAX prenyl protease 1 homolog (ZMPSTE24) ELISA Kit

 Product Gene Name   

ZMPSTE24 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    gene 608612
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 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of ZMPSTE24 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ZMPSTE24 purchase    MBS7229246 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CAAX prenyl protease 1 homolog (ZMPSTE24) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ZMPSTE24. The ELISA analytical biochemical technique of the MBS7229246 kit is based on ZMPSTE24 antibody-ZMPSTE24 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ZMPSTE24 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ZMPSTE24. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for ZMPSTE24 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for ZMPSTE24. It may not necessarily be applicable to this product.
 NCBI GI #    18379366
 NCBI GeneID    10269
 NCBI Accession #    NP_005848.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005857.4 [Other Products]
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 UniProt Secondary Accession #    Q8NDZ8; Q9UBQ2; B3KQI7; D3DPU7 [Other Products]
 UniProt Related Accession #    O75844 [Other Products]
 Molecular Weight    54,813 Da
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 NCBI Official Full Name    CAAX prenyl protease 1 homolog
 NCBI Official Synonym Full Names    zinc metallopeptidase STE24
 NCBI Official Symbol    ZMPSTE24 [Similar Products]
 NCBI Official Synonym Symbols   
HGPS; PRO1; FACE1; STE24; FACE-1; Ste24p
[Similar Products]
 NCBI Protein Information    CAAX prenyl protease 1 homolog; zinc metallopeptidase STE24 homolog; zinc metalloproteinase Ste24 homolog; prenyl protein-specific endoprotease 1; farnesylated proteins-converting enzyme 1
 UniProt Protein Name    CAAX prenyl protease 1 homolog
 UniProt Synonym Protein Names   
Farnesylated proteins-converting enzyme 1; FACE-1; Prenyl protein-specific endoprotease 1; Zinc metalloproteinase Ste24 homolog
 UniProt Gene Name    ZMPSTE24 [Similar Products]
 UniProt Synonym Gene Names    FACE1; STE24; FACE-1 [Similar Products]
 UniProt Entry Name    FACE1_HUMAN
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 NCBI Summary for ZMPSTE24    This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ZMPSTE24    ZMPSTE24: Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. Defects in ZMPSTE24 are the cause of mandibuloacral dysplasia with type B lipodystrophy (MADB). Mandibuloacral dysplasia (MAD) is a rare autosomal recessive disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, joint contractures, and types A or B patterns of lipodystrophy. Type B lipodystrophy observed in MADB, is characterized by generalized fat loss. Defects in ZMPSTE24 are a cause of lethal tight skin contracture syndrome (LTSCS); also called restrictive dermopathy (RD). Lethal tight skin contracture syndrome is a rare disorder mainly characterized by intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia, multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance. Belongs to the peptidase M48A family.

Protein type: Protease; Membrane protein, integral; Membrane protein, multi-pass; EC 3.4.24.84

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane; nuclear inner membrane

Molecular Function: metalloexopeptidase activity; metal ion binding; metalloendopeptidase activity

Biological Process: prenylated protein catabolic process; proteolysis; nuclear membrane organization and biogenesis

Disease: Restrictive Dermopathy, Lethal; Mandibuloacral Dysplasia With Type B Lipodystrophy
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 Research Articles on ZMPSTE24    1. miR-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ZMPSTE24 elisa kitPathways associated with ZMPSTE24 elisa kit
 Reference Product  PubMed Publications
 LMNA elisa kit  >69 publications with ZMPSTE24 and LMNA
 RCE1 elisa kit  >9 publications with ZMPSTE24 and RCE1
 ICMT elisa kit  >7 publications with ZMPSTE24 and ICMT
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
 Terpenoid Backbone Biosynthesis Pathway antibodies  Terpenoid Backbone Biosynthesis Pathway Diagram
Diseases associated with ZMPSTE24 elisa kitOrgans/Tissues associated with ZMPSTE24 elisa kit
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >36 publications with ZMPSTE24 and Congenital Abnormalities
 Lipodystrophy Antibodies  >34 publications with ZMPSTE24 and Lipodystrophy
 Tight skin contracture syndrome, lethal Antibodies  >7 publications with ZMPSTE24 and Tight skin contracture syndrome, lethal
 Mandibular Diseases Antibodies  >5 publications with ZMPSTE24 and Mandibular Diseases
 Acro-Osteolysis Antibodies  >5 publications with ZMPSTE24 and Acro-Osteolysis
 Heart Diseases Antibodies  >5 publications with ZMPSTE24 and Heart Diseases
 HIV-Associated Lipodystrophy Syndrome Antibodies  >5 publications with ZMPSTE24 and HIV-Associated Lipodystrophy Syndrome
 Craniofacial Abnormalities Antibodies  >5 publications with ZMPSTE24 and Craniofacial Abnormalities
 Fetal Growth Retardation Antibodies  >3 publications with ZMPSTE24 and Fetal Growth Retardation
 Weight Gain Antibodies  >3 publications with ZMPSTE24 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >49 publications with ZMPSTE24 and Skin
 Bone Antibodies  >31 publications with ZMPSTE24 and Bone
 Connective Tissue Antibodies  >15 publications with ZMPSTE24 and Connective Tissue
 Muscle Antibodies  >13 publications with ZMPSTE24 and Muscle
 Blood Antibodies  >10 publications with ZMPSTE24 and Blood
 Adipose Tissue Antibodies  >9 publications with ZMPSTE24 and Adipose Tissue
 Mouth Antibodies  >7 publications with ZMPSTE24 and Mouth
 Liver Antibodies  >5 publications with ZMPSTE24 and Liver
 Heart Antibodies  >4 publications with ZMPSTE24 and Heart
 Bone Marrow Antibodies  >4 publications with ZMPSTE24 and Bone Marrow
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