NP_034080.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,656 Da
NCBI Official Full Name
death domain-containing protein CRADD
NCBI Official Synonym Full Names
CASP2 and RIPK1 domain containing adaptor with death domain
NCBI Official Synonym Symbols
NCBI Protein Information
death domain-containing protein CRADD; caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CASP2 and RIPK1 domain-containing adaptor with death domain
UniProt Protein Name
Death domain-containing protein CRADD
UniProt Synonym Protein Names
Caspase and RIP adapter with death domain; RIP-associated protein with a death domain
UniProt Synonym Gene Names
UniProt Entry Name
CRADD_MOUSE
UniProt Comments for CRADD
CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.
Protein type: Adaptor/scaffold; Apoptosis
Cellular Component: cytoplasm; intracellular; nucleus
Molecular Function: protein binding, bridging; protease binding
Biological Process: caspase activation; regulation of apoptosis; apoptosis; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Research Articles on CRADD
Precautions
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Pathways associated with CRADD elisa kit
Diseases associated with CRADD elisa kit
Organs/Tissues associated with CRADD elisa kit
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