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CASP7 elisa kit :: Mouse CASP7 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2505345
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CASP7, ELISA Kit

★Popular Item★
 Also Known As   

Mouse CASP7 (Caspase 7) ELISA Kit

 Product Gene Name   

CASP7 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601761
 3D Structure    ModBase 3D Structure for P55210
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Mouse CASP7. No significant cross-reactivity or interference between Mouse CASP7 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse CASP7 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156--10ng/mL
 Sensitivity    0.094ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CASP7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CASP7 purchase    MBS2505345 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CASP7, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156--10ng/mL in biological research samples containing CASP7, with an estimated sensitivity of 0.094ng/mL. The ELISA analytical biochemical technique of the MBS2505345 kit is based on CASP7 antibody-CASP7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CASP7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CASP7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CASP7 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CASP7 in Mouse serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse CASP7. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse CASP7 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse CASP7, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse CASP7. You can calculate the concentration of Mouse CASP7 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CASP7 elisa kit    CASP7 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2505345. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CASP7. It may not necessarily be applicable to this product.
 NCBI GI #    388596700
 NCBI GeneID    840
 NCBI Accession #    NP_001253986.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001267057.1 [Other Products]
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 UniProt Primary Accession #    P55210 [Other Products]
 UniProt Secondary Accession #    Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0; B4DQU7; B5BU45; D3DRB8 [Other Products]
 UniProt Related Accession #    P55210 [Other Products]
 Molecular Weight    31,614 Da
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 NCBI Official Full Name    caspase-7 isoform e
 NCBI Official Synonym Full Names    caspase 7, apoptosis-related cysteine peptidase
 NCBI Official Symbol    CASP7 [Similar Products]
 NCBI Official Synonym Symbols   
MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3
[Similar Products]
 NCBI Protein Information    caspase-7; ICE-like apoptotic protease 3; apoptotic protease MCH-3; caspase 7, apoptosis-related cysteine protease
 UniProt Protein Name    Caspase-7
 UniProt Synonym Protein Names   
Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
 Protein Family    Caspase
 UniProt Gene Name    CASP7 [Similar Products]
 UniProt Synonym Gene Names    MCH3; CASP-7; ICE-LAP3 [Similar Products]
 UniProt Entry Name    CASP7_HUMAN
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 NCBI Summary for CASP7    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for CASP7    CASP7: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Mitochondrial; Protease; EC 3.4.22.60; Apoptosis

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: apoptosis; caspase activation via cytochrome c; proteolysis; cell structure disassembly during apoptosis
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 Research Articles on CASP7    1. Phosphorylate caspase-7 bu Src at multiple tyrosine sites enhanced its cellular apoptotic effect.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CASP7 elisa kitPathways associated with CASP7 elisa kit
 Reference Product  PubMed Publications
 CASP9 elisa kit  >388 publications with CASP7 and CASP9
 CASP8 elisa kit  >277 publications with CASP7 and CASP8
 XIAP elisa kit  >80 publications with CASP7 and XIAP
 BIRC5 elisa kit  >45 publications with CASP7 and BIRC5
 PARP1 elisa kit  >39 publications with CASP7 and PARP1
 APAF1 elisa kit  >33 publications with CASP7 and APAF1
 GZMB elisa kit  >20 publications with CASP7 and GZMB
 BIRC2 elisa kit  >7 publications with CASP7 and BIRC2
 BIRC3 elisa kit  >5 publications with CASP7 and BIRC3
 RB1 elisa kit  >4 publications with CASP7 and RB1
 Products by Pathway  Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
Diseases associated with CASP7 elisa kitOrgans/Tissues associated with CASP7 elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >268 publications with CASP7 and Necrosis
 Breast Neoplasms Antibodies  >171 publications with CASP7 and Breast Neoplasms
 Inflammation Antibodies  >99 publications with CASP7 and Inflammation
 Nervous System Diseases Antibodies  >82 publications with CASP7 and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >67 publications with CASP7 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >60 publications with CASP7 and Neoplasms, Experimental
 Liver Diseases Antibodies  >59 publications with CASP7 and Liver Diseases
 Cardiovascular Diseases Antibodies  >58 publications with CASP7 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >33 publications with CASP7 and Kidney Diseases
 Liver Neoplasms Antibodies  >33 publications with CASP7 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >185 publications with CASP7 and Blood
 Lung Antibodies  >119 publications with CASP7 and Lung
 Brain Antibodies  >116 publications with CASP7 and Brain
 Liver Antibodies  >113 publications with CASP7 and Liver
 Prostate Antibodies  >79 publications with CASP7 and Prostate
 Muscle Antibodies  >71 publications with CASP7 and Muscle
 Vascular Antibodies  >71 publications with CASP7 and Vascular
 Kidney Antibodies  >70 publications with CASP7 and Kidney
 Nerve Antibodies  >61 publications with CASP7 and Nerve
 Bone Antibodies  >55 publications with CASP7 and Bone
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