NP_034690.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,451 Da
NCBI Official Full Name
interleukin-6 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Synonym Symbols
CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik [Similar Products]
NCBI Protein Information
interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha
UniProt Protein Name
Interleukin-6 receptor subunit beta
UniProt Synonym Protein Names
Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130 [Similar Products]
UniProt Entry Name
IL6RB_MOUSE
UniProt Comments for IL6ST
gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: extracellular space; membrane; cell soma; oncostatin-M receptor complex; dendrite; integral to membrane; interleukin-6 receptor complex; cytosol; external side of plasma membrane
Molecular Function: interleukin-11 binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 receptor binding; interleukin-6 binding; protein heterodimerization activity; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding
Biological Process: glycogen metabolic process; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; signal transduction; positive regulation of smooth muscle cell migration; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; reduction of cytosolic calcium ion concentration; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; triacylglycerol mobilization; positive regulation of astrocyte differentiation
Research Articles on IL6ST
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Pathways associated with IL6ST elisa kit
Diseases associated with IL6ST elisa kit
Organs/Tissues associated with IL6ST elisa kit
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