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CTNNa1 elisa kit :: Mouse CTNNa1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2513712
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CTNNa1, ELISA Kit

★Popular Item★
 Also Known As   

Mouse CTNNa1 (Catenin, Alpha 1) ELISA Kit

 Product Gene Name   

CTNNa1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    116805
 3D Structure    ModBase 3D Structure for P35221
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 Species Reactivity    Mouse
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 Specificity    This kit recognizes natural and recombinant Mouse CTNNa1. No significant cross-reactivity or interference between Mouse CTNNa1 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    78.125-5000pg/mL
 Sensitivity    Min: 46.875pg/mL; Max: 5000pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CTNNa1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CTNNa1 purchase    MBS2513712 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CTNNa1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 78.125-5000pg/mL in biological research samples containing CTNNa1, with an estimated sensitivity of Min: 46.875pg/mL; Max: 5000pg/mL. The ELISA analytical biochemical technique of the MBS2513712 kit is based on CTNNa1 antibody-CTNNa1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CTNNa1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CTNNa1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CTNNa1 elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Mouse CTNNa1 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CTNNa1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CTNNa1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CTNNa1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CTNNa1. You can calculate the concentration of CTNNa1 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CTNNa1 elisa kit    CTNNa1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2513712. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CTNNa1. It may not necessarily be applicable to this product.
 NCBI GI #    55770844
 NCBI GeneID    1495
 NCBI Accession #    NP_001894.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001903.3 [Other Products]
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 UniProt Primary Accession #    P35221 [Other Products]
 UniProt Secondary Accession #    Q12795; Q8N1C0 [Other Products]
 UniProt Related Accession #    P35221 [Other Products]
 Molecular Weight    59,550 Da
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 NCBI Official Full Name    catenin alpha-1 isoform 1
 NCBI Official Synonym Full Names    catenin (cadherin-associated protein), alpha 1, 102kDa
 NCBI Official Symbol    CTNNA1 [Similar Products]
 NCBI Official Synonym Symbols   
CAP102
[Similar Products]
 NCBI Protein Information    catenin alpha-1; alpha E-catenin; alpha-E-catenin; alpha-catenin; alphaE-catenin; cadherin-associated protein,102kDa; renal carcinoma antigen NY-REN-13
 UniProt Protein Name    Catenin alpha-1
 UniProt Synonym Protein Names   
Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13
 Protein Family    Catenin
 UniProt Gene Name    CTNNA1 [Similar Products]
 UniProt Entry Name    CTNA1_HUMAN
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 UniProt Comments for CTNNa1    CTNNA1: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma- catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F- actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1. Expressed ubiquitously in normal tissues. Belongs to the vinculin/alpha-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: focal adhesion; lamellipodium; acrosome; plasma membrane; zonula adherens; catenin complex; intercellular junction; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; cadherin binding; gamma-catenin binding; beta-catenin binding; structural molecule activity; vinculin binding

Biological Process: intercellular junction assembly and maintenance; apical junction assembly; gap junction assembly; protein heterooligomerization; axon regeneration; male gonad development; establishment and/or maintenance of cell polarity; actin filament organization; odontogenesis of dentine-containing teeth; muscle cell differentiation; negative regulation of neuroblast proliferation; ovarian follicle development; response to estrogen stimulus; positive regulation of smoothened signaling pathway; positive regulation of muscle cell differentiation; vascular endothelial growth factor receptor signaling pathway; cell adhesion; aging
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 Research Articles on CTNNa1    1. CTNNA1 methylation is a recurrent event but has no influence on prognosis in acute myeloid leukemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTNNa1 elisa kitPathways associated with CTNNa1 elisa kit
 Reference Product  PubMed Publications
 CTNNB1 elisa kit  >402 publications with CTNNa1 and CTNNB1
 JUP elisa kit  >86 publications with CTNNa1 and JUP
 TJP1 elisa kit  >19 publications with CTNNa1 and TJP1
 CDH1 elisa kit  >10 publications with CTNNa1 and CDH1
 CDH2 elisa kit  >3 publications with CTNNa1 and CDH2
 VCL elisa kit  >2 publications with CTNNa1 and VCL
 CTNND1 elisa kit  >1 publications with CTNNa1 and CTNND1
 CDH5 elisa kit  >1 publications with CTNNa1 and CDH5
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
Diseases associated with CTNNa1 elisa kitOrgans/Tissues associated with CTNNa1 elisa kit
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >213 publications with CTNNa1 and Carcinoma
 Breast Neoplasms Antibodies  >48 publications with CTNNa1 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >31 publications with CTNNa1 and Carcinoma, Squamous Cell
 Liver Neoplasms Antibodies  >28 publications with CTNNa1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >23 publications with CTNNa1 and Lung Neoplasms
 Lung Diseases Antibodies  >22 publications with CTNNa1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >19 publications with CTNNa1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >17 publications with CTNNa1 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >16 publications with CTNNa1 and Kidney Diseases
 Pancreatic Neoplasms Antibodies  >16 publications with CTNNa1 and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Antibodies  >53 publications with CTNNa1 and Lymph
 Lymph Node Antibodies  >53 publications with CTNNa1 and Lymph Node
 Liver Antibodies  >37 publications with CTNNa1 and Liver
 Stomach Antibodies  >30 publications with CTNNa1 and Stomach
 Vascular Antibodies  >29 publications with CTNNa1 and Vascular
 Prostate Antibodies  >29 publications with CTNNa1 and Prostate
 Embryonic Tissue Antibodies  >27 publications with CTNNa1 and Embryonic Tissue
 Blood Antibodies  >26 publications with CTNNa1 and Blood
 Kidney Antibodies  >25 publications with CTNNa1 and Kidney
 Lung Antibodies  >25 publications with CTNNa1 and Lung
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