CAG33228.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,552 Da
NCBI Official Full Name
CTSD
NCBI Official Synonym Full Names
cathepsin D
NCBI Protein Information
cathepsin D; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease
UniProt Protein Name
Cathepsin D
UniProt Synonym Gene Names
UniProt Entry Name
CATD_HUMAN
NCBI Summary for CTSD
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
UniProt Comments for CTSD
CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.
Protein type: EC 3.4.23.5; Protease; Motility/polarity/chemotaxis; Autophagy
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; lysosome; extracellular region; melanosome
Molecular Function: protein binding; aspartic-type endopeptidase activity
Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis
Disease: Ceroid Lipofuscinosis, Neuronal, 10
Research Articles on CTSD
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Products associated with CTSD elisa kit
Pathways associated with CTSD elisa kit
Diseases associated with CTSD elisa kit
Organs/Tissues associated with CTSD elisa kit
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