NP_067628.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,099 Da
NCBI Official Full Name
carbohydrate sulfotransferase 6
NCBI Official Synonym Full Names
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
NCBI Official Synonym Symbols
NCBI Protein Information
carbohydrate sulfotransferase 6; gn6st-5; hCGn6ST; GST4-beta; C-GlcNAc6ST; glcNAc6ST-5; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sulfotransferase; corneal N-acetylglucosamine-6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta
UniProt Protein Name
Carbohydrate sulfotransferase 6
UniProt Synonym Protein Names
Corneal N-acetylglucosamine-6-O-sulfotransferase; C-GlcNAc6ST; hCGn6ST; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta; GST4-beta; N-acetylglucosamine 6-O-sulfotransferase 5; GlcNAc6ST-5; Gn6st-5
UniProt Synonym Gene Names
UniProt Entry Name
CHST6_HUMAN
NCBI Summary for CHST6
The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq, Jan 2010]
UniProt Comments for CHST6
CHST6: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. Defects in CHST6 are the cause of macular corneal dystrophy (MCD). MCD is an autosomal recessive disease characterized by corneal opacities. Onset occurs in the first decade, usually between ages 5 and 9. The disorder is progressive. Minute, gray, punctate opacities develop. Corneal sensitivity is usually reduced. Painful attacks with photophobia, foreign body sensations, and recurrent erosions occur in most patients. There are different types of MCD: MCD type I, in which there is a virtual absence of sulfated keratan sulfate (KS) in the serum and cornea, as determined by KS-specific antibodies; and MCD type II, in which the normal sulfated KS-antibody response is present in cornea and serum. MCD type I patients usually have a homozygous missense mutation, while MCD type II patients show a large deletion and replacement in the upstream region of CHST6. The only missense mutation for type II is Cys-50, which is heterozygous with a replacement in the upstream region on the other allele of CHST6. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Protein type: Glycan Metabolism - keratan sulfate biosynthesis; EC 2.8.2.-; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 16q22
Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane
Molecular Function: N-acetylglucosamine 6-O-sulfotransferase activity
Biological Process: keratan sulfate metabolic process; sulfur metabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; N-acetylglucosamine metabolic process; keratan sulfate biosynthetic process; pathogenesis
Disease: Macular Dystrophy, Corneal, 1
Research Articles on CHST6
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Products associated with CHST6 elisa kit
Pathways associated with CHST6 elisa kit
Diseases associated with CHST6 elisa kit
Organs/Tissues associated with CHST6 elisa kit
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