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COMP elisa kit :: Mouse Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2020849 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $245 +1 FREE 8GB USB
48-Strip-Wells  /  $425 +1 FREE 8GB USB
96-Strip-Wells  /  $565 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,275 +2 FREE 8GB USB
10x96-Strip-Wells  /  $4,100 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cartilage Oligomeric Matrix Protein (COMP), ELISA Kit

★Popular Item★
 Also Known As   

Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit

 Product Synonym Names    MED; EDM1; EPD1; PSACH; THBS5; TSP-5; Pseudoachondroplasia,Epiphyseal Dysplasia 1,Multiple; Thrombospondin 5
 Product Gene Name   

COMP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    132400
 3D Structure    ModBase 3D Structure for P49747
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Cartilage Oligomeric Matrix Protein (COMP).
No significant cross-reactivity or interference between Cartilage Oligomeric Matrix Protein (COMP) and analogues was observed.
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 Assay Type    Double-antibody Sandwich
 Samples    Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and Other Biological Fluids
 Detection Range    0.156-10ng/mL
 Sensitivity    < 0.057ng/mL
 Application    Enzyme-linked immunosorbent assay for Antigen Detection.
 Intra-assay Precision (Precision within an assay)    3 samples with low, middle and high level Cartilage Oligomeric Matrix Protein (COMP) were tested 20 times on one plate, respectively.
 Inter-assay Precision (Precision between assays)    3 samples with low, middle and high level Cartilage Oligomeric Matrix Protein (COMP) were tested on 3 different plates, 8 replicates in each plate.
 CV(%) =    SD/meanX100
 Intra-Assay    CV<10%
 Inter-Assay    CV<12%
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 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COMP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COMP purchase    MBS2020849 is a ready-to-use microwell, strip plate Double-antibody Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing COMP, with an estimated sensitivity of < 0.057ng/mL. The ELISA analytical biochemical technique of the MBS2020849 kit is based on COMP antibody-COMP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COMP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COMP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and Other Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for COMP elisa kit

   The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Cartilage Oligomeric Matrix Protein (COMP). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Cartilage Oligomeric Matrix Protein (COMP). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Cartilage Oligomeric Matrix Protein (COMP), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Cartilage Oligomeric Matrix Protein (COMP) in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Product Categories/Family for COMP elisa kit    Metabolic pathway; Bone metabolism
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 Typical Testing Data/Standard Curve (for reference only) of COMP elisa kit    COMP elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2020849. Click to request current manual
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NCBI/Uniprot data below describe general gene information for COMP. It may not necessarily be applicable to this product.
 NCBI GI #    40217843
 NCBI GeneID    1311
 NCBI Accession #    NP_000086.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000095.2 [Other Products]
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 UniProt Primary Accession #    P49747 [Other Products]
 UniProt Secondary Accession #    O14592; Q16388; Q16389; Q2NL86; Q8N4T2; B4DKJ3 [Other Products]
 UniProt Related Accession #    P49747 [Other Products]
 Molecular Weight    77,214 Da
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 NCBI Official Full Name    cartilage oligomeric matrix protein
 NCBI Official Synonym Full Names    cartilage oligomeric matrix protein
 NCBI Official Symbol    COMP [Similar Products]
 NCBI Official Synonym Symbols   
MED; EDM1; EPD1; PSACH; THBS5
[Similar Products]
 NCBI Protein Information    cartilage oligomeric matrix protein
 UniProt Protein Name    Cartilage oligomeric matrix protein
 UniProt Synonym Protein Names   
Thrombospondin-5; TSP5
 Protein Family    Cartilage oligomeric matrix protein
 UniProt Gene Name    COMP [Similar Products]
 UniProt Synonym Gene Names    COMP; TSP5 [Similar Products]
 UniProt Entry Name    COMP_HUMAN
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 NCBI Summary for COMP    The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]
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 UniProt Comments for COMP    COMP: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 (EDM1). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. Defects in COMP are the cause of pseudoachondroplasia (PSACH). PSAC is a dominantly inherited chondrodysplasia characterized by short stature and early-onset osteoarthrosis. PSACH is more severe than EDM1 and is recognized in early childhood. Belongs to the thrombospondin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: collagen binding; heparin binding; heparan sulfate proteoglycan binding; protein binding; protease binding; extracellular matrix structural constituent; calcium ion binding

Biological Process: limb development; extracellular matrix organization and biogenesis; organ morphogenesis; apoptosis; cell adhesion; skeletal development; negative regulation of apoptosis

Disease: Epiphyseal Dysplasia, Multiple, 1; Pseudoachondroplasia
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 Research Articles on COMP    1. COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COMP elisa kitPathways associated with COMP elisa kit
 Reference Product  PubMed Publications
 MATN1 elisa kit  >68 publications with COMP and MATN1
 SOX9 elisa kit  >64 publications with COMP and SOX9
 CD36 elisa kit  >42 publications with COMP and CD36
 COL2A1 elisa kit  >34 publications with COMP and COL2A1
 EGR1 elisa kit  >22 publications with COMP and EGR1
 BMP2 elisa kit  >14 publications with COMP and BMP2
 HDAC1 elisa kit  >6 publications with COMP and HDAC1
 ITGA2B elisa kit  >2 publications with COMP and ITGA2B
 Products by Pathway  Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with COMP elisa kitOrgans/Tissues associated with COMP elisa kit
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1775 publications with COMP and Disease Models, Animal
 Inflammation Antibodies  >1189 publications with COMP and Inflammation
 Necrosis Antibodies  >1036 publications with COMP and Necrosis
 Nerve Degeneration Antibodies  >958 publications with COMP and Nerve Degeneration
 Liver Diseases Antibodies  >891 publications with COMP and Liver Diseases
 Kidney Diseases Antibodies  >707 publications with COMP and Kidney Diseases
 Hypertension Antibodies  >665 publications with COMP and Hypertension
 Fatty Liver Antibodies  >616 publications with COMP and Fatty Liver
 Weight Loss Antibodies  >574 publications with COMP and Weight Loss
 Weight Gain Antibodies  >520 publications with COMP and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22182 publications with COMP and Brain
 Liver Antibodies  >6663 publications with COMP and Liver
 Heart Antibodies  >4386 publications with COMP and Heart
 Intestine Antibodies  >3275 publications with COMP and Intestine
 Vascular Antibodies  >2839 publications with COMP and Vascular
 Skin Antibodies  >2640 publications with COMP and Skin
 Bone Antibodies  >2126 publications with COMP and Bone
 Ovary Antibodies  >1995 publications with COMP and Ovary
 Connective Tissue Antibodies  >1815 publications with COMP and Connective Tissue
 Embryonic Tissue Antibodies  >1798 publications with COMP and Embryonic Tissue
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