AAC53196.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,475 Da
NCBI Official Full Name
CPP32
NCBI Official Synonym Full Names
caspase 3
NCBI Official Synonym Symbols
CC3; AC-3; Lice; Yama; mldy; CPP32; Apopain; Caspase-3; A830040C14Rik [Similar Products]
NCBI Protein Information
caspase-3; SCA-1; CASP-3; CPP-32; protein Yama; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis related cysteine protease
UniProt Protein Name
Caspase-3
UniProt Synonym Protein Names
Apopain; Cysteine protease CPP32; CPP-32; LICE; Protein Yama; SREBP cleavage activity 1
UniProt Synonym Gene Names
UniProt Entry Name
CASP3_MOUSE
UniProt Comments for CPP32
CASP3: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family.
Protein type: Motility/polarity/chemotaxis; Protease; EC 3.4.22.56; Apoptosis
Cellular Component: cytoplasm; nucleus; cytosol; lipid raft
Molecular Function: cyclin-dependent protein kinase inhibitor activity; peptidase activity; protein binding; phospholipase A2 activator activity; protease binding; hydrolase activity; cysteine-type endopeptidase activity; death receptor binding; protein complex binding; aspartic-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: positive regulation of catalytic activity; apoptosis; positive regulation of apoptosis; negative regulation of activated T cell proliferation; heart development; negative regulation of B cell proliferation; proteolysis; negative regulation of cell cycle; neuron differentiation; sensory perception of sound; learning and/or memory; B cell homeostasis; positive regulation of neuron apoptosis; response to glucose stimulus; response to wounding; erythrocyte differentiation; T cell homeostasis; response to UV; release of cytochrome c from mitochondria; cell fate commitment; negative regulation of cyclin-dependent protein kinase activity; keratinocyte differentiation; neuron apoptosis; induction of apoptosis via death domain receptors; response to hydrogen peroxide; protein processing; induction of apoptosis by oxidative stress; response to DNA damage stimulus; negative regulation of apoptosis
Research Articles on CPP32
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Pathways associated with CPP32 elisa kit
Diseases associated with CPP32 elisa kit
Organs/Tissues associated with CPP32 elisa kit
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