NP_940818.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,104 Da
NCBI Official Full Name
charged multivesicular body protein 2a
NCBI Official Synonym Full Names
charged multivesicular body protein 2A
NCBI Protein Information
charged multivesicular body protein 2a; vps2-1; VPS2 homolog A; chromatin modifying protein 2A; putative breast adenocarcinoma marker BC-2; putative breast adenocarcinoma marker (32kD); vacuolar protein sorting-associated protein 2-1
UniProt Protein Name
Charged multivesicular body protein 2a
UniProt Synonym Protein Names
Chromatin-modifying protein 2a; CHMP2a; Putative breast adenocarcinoma marker BC-2; Vacuolar protein sorting-associated protein 2-1; Vps2-1; hVps2-1
UniProt Synonym Gene Names
UniProt Entry Name
CHM2A_HUMAN
NCBI Summary for CHMP2A
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
UniProt Comments for CHMP2A
CHMP2A: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV- 1 p6- and p9-dependent virus release. Belongs to the SNF7 family.
Chromosomal Location of Human Ortholog: 19q
Cellular Component: membrane coat; membrane; late endosome membrane; cytosol
Molecular Function: protein domain specific binding; protein binding; phosphatidylcholine binding
Biological Process: protein polymerization; protein transport; establishment of protein localization; viral reproduction; cell separation during cytokinesis; protein heterooligomerization; vacuolar transport; membrane invagination; regulation of viral reproduction; viral infectious cycle; endosome transport; mitotic metaphase plate congression; nuclear organization and biogenesis; protein homooligomerization
Research Articles on CHMP2A
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Products associated with CHMP2A elisa kit
Pathways associated with CHMP2A elisa kit
Diseases associated with CHMP2A elisa kit
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