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F8 elisa kit :: Mouse Coagulation Factor VIII ELISA Kit

Scan QR to view Datasheet Catalog #    MBS021184 F8 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Coagulation Factor VIII (F8), ELISA Kit

 Also Known As   

Mouse Coagulation Factor VIII ELISA Kit

 Product Gene Name   

F8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 Chromosome Location    Chromosome: X; NC_000086.7 (75172715..75380041, complement). Location: X A7-B; X 38.17 cM
 3D Structure    ModBase 3D Structure for Q06194
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 Species Reactivity    Mouse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of F8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for F8 purchase    MBS021184 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Coagulation Factor VIII (F8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing F8. The ELISA analytical biochemical technique of the MBS021184 kit is based on F8 antibody-F8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect F8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, F8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Sample Manual Insert of MBS021184
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NCBI/Uniprot data below describe general gene information for F8. It may not necessarily be applicable to this product.
 NCBI GI #    238624180
 NCBI GeneID    14069
 NCBI Accession #    NP_032003.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007977.2 [Other Products]
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 UniProt Primary Accession #    Q06194 [Other Products]
 UniProt Secondary Accession #    A2AN88 [Other Products]
 UniProt Related Accession #    Q06194 [Other Products]
 Molecular Weight    266,196 Da
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 NCBI Official Full Name    coagulation factor VIII isoform 1
 NCBI Official Synonym Full Names    coagulation factor VIII
 NCBI Official Symbol    F8 [Similar Products]
 NCBI Official Synonym Symbols   
Cf8; Cf-8; FVIII
[Similar Products]
 NCBI Protein Information    coagulation factor VIII; Factor VIII; procoagulant component
 UniProt Protein Name    Coagulation factor VIII
 UniProt Synonym Protein Names   
Procoagulant component
 Protein Family    Coagulation factor
 UniProt Gene Name    F8 [Similar Products]
 UniProt Synonym Gene Names    Cf8; F8c [Similar Products]
 UniProt Entry Name    FA8_MOUSE
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 UniProt Comments for F8    F8: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Defects in F8 are the cause of hemophilia A (HEMA). A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non- functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: copper ion binding; serine-type endopeptidase activity; metal ion binding; oxidoreductase activity

Biological Process: platelet activation; hemostasis; acute-phase response; proteolysis; blood coagulation; blood coagulation, intrinsic pathway
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 Research Articles on F8    1. Acute elevations in FVIII levels result in a non-linear thrombogenic effect, with non-significant increases in thrombogenic risk. Prolonged elevation of plasma FVIII did not further increase the thrombogenic potential of elevated FVIII levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with F8 elisa kitDiseases associated with F8 elisa kit
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Hemophilia A Antibodies  >454 publications with F8 and Hemophilia A
 Hemorrhage Antibodies  >122 publications with F8 and Hemorrhage
 Neoplasms Antibodies  >96 publications with F8 and Neoplasms
 Nervous System Diseases Antibodies  >96 publications with F8 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >83 publications with F8 and Cardiovascular Diseases
 Thrombosis Antibodies  >63 publications with F8 and Thrombosis
 Brain Diseases Antibodies  >45 publications with F8 and Brain Diseases
 Kidney Diseases Antibodies  >27 publications with F8 and Kidney Diseases
 Venous Thrombosis Antibodies  >24 publications with F8 and Venous Thrombosis
 Inflammation Antibodies  >19 publications with F8 and Inflammation
Organs/Tissues associated with F8 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >271 publications with F8 and Other
 Heart Antibodies  >34 publications with F8 and Heart
 Liver Antibodies  >31 publications with F8 and Liver
 Lung Antibodies  >21 publications with F8 and Lung
 Spleen Antibodies  >15 publications with F8 and Spleen
 Embryonic Tissue Antibodies  >4 publications with F8 and Embryonic Tissue
 Pancreas Antibodies  >2 publications with F8 and Pancreas
 Dorsal Root Ganglion Antibodies  >1 publications with F8 and Dorsal Root Ganglion
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