NP_067464.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,701 Da
NCBI Official Full Name
coagulation factor XII preproprotein
NCBI Official Synonym Full Names
coagulation factor XII (Hageman factor)
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor XII
UniProt Protein Name
Coagulation factor XII
UniProt Synonym Protein Names
Hageman factor; HAF
UniProt Synonym Gene Names
NCBI Summary for F12
This gene encodes a glycoprotein coagulation factor that plays an important role in the intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that is autoactivated upon contact with negatively charged surfaces or misfolded protein aggregates. Mice lacking the encoded protein have a severe defect in forming stable fibrin clots. [provided by RefSeq, Apr 2015]
UniProt Comments for F12
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa ().
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Products associated with F12 elisa kit
Pathways associated with F12 elisa kit
Diseases associated with F12 elisa kit
Organs/Tissues associated with F12 elisa kit
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