NP_082342.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,789 Da
NCBI Official Full Name
coagulation factor XI preproprotein
NCBI Official Synonym Full Names
coagulation factor XI
NCBI Official Synonym Symbols
FXI; PTA; Cf11; AI503996; 1600027G01Rik [Similar Products]
NCBI Protein Information
coagulation factor XI
UniProt Protein Name
Coagulation factor XI
UniProt Synonym Protein Names
Plasma thromboplastin antecedent; PTA
UniProt Synonym Gene Names
NCBI Summary for F11
This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]
UniProt Comments for F11
F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.27; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8 B1.1|8 25.14 cM
Cellular Component: extracellular space
Biological Process: blood coagulation; plasminogen activation; positive regulation of fibrinolysis; regulation of blood coagulation
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Pathways associated with F11 elisa kit
Diseases associated with F11 elisa kit
Organs/Tissues associated with F11 elisa kit
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