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Col3a1 elisa kit :: Mouse Collagen alpha-1(III) chain ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2887718
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen alpha-1(III) chain (Col3a1), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Collagen alpha-1(III) chain ELISA Kit

 Product Synonym Names    Collagen alpha-1(III) chain; Col3a1
 Product Gene Name   

Col3a1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2887718 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for P08121
 Species Reactivity    Mouse
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 Samples    Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Col3a1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Col3a1 purchase    MBS2887718 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen alpha-1(III) chain (Col3a1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Col3a1. The ELISA analytical biochemical technique of the MBS2887718 kit is based on Col3a1 antibody-Col3a1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Col3a1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Col3a1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for Col3a1 elisa kit

   Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of Col3a1 elisa kit    Col3a1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2887718. Click to request current manual
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NCBI/Uniprot data below describe general gene information for Col3a1. It may not necessarily be applicable to this product.
 NCBI GI #    226423933
 NCBI GeneID    12825
 NCBI Accession #    NP_034060.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009930.2 [Other Products]
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 UniProt Primary Accession #    P08121 [Other Products]
 UniProt Secondary Accession #    Q61429; Q9CRN7 [Other Products]
 UniProt Related Accession #    P08121 [Other Products]
 Molecular Weight    138,943 Da
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 NCBI Official Full Name    collagen alpha-1(III) chain preproprotein
 NCBI Official Synonym Full Names    collagen, type III, alpha 1
 NCBI Official Symbol    Col3a1 [Similar Products]
 NCBI Official Synonym Symbols   
Tsk2; Tsk-2; Col3a-1; AW550625
[Similar Products]
 NCBI Protein Information    collagen alpha-1(III) chain
 UniProt Protein Name    Collagen alpha-1(III) chain
 Protein Family    Collagen
 UniProt Gene Name    Col3a1 [Similar Products]
 UniProt Entry Name    CO3A1_MOUSE
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 NCBI Summary for Col3a1    This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named "tight skin 2" exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015]
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 UniProt Comments for Col3a1    CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Extracellular matrix; Secreted, signal peptide; Cell adhesion

Cellular Component: collagen; collagen type III; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent; integrin binding; metal ion binding; platelet-derived growth factor binding; SMAD binding

Biological Process: blood vessel development; cell-matrix adhesion; cerebral cortex development; collagen fibril organization; fibril organization and biogenesis; gut development; heart development; integrin-mediated signaling pathway; negative regulation of immune response; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine stimulus; response to radiation; skin development; transforming growth factor beta receptor signaling pathway; wound healing
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 Research Articles on Col3a1    1. Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Col3a1 elisa kitPathways associated with Col3a1 elisa kit
 Reference Product  PubMed Publications
 Col1a1 elisa kit  >223 publications with Col3a1 and Col1a1
 Col1a2 elisa kit  >100 publications with Col3a1 and Col1a2
 Col5a1 elisa kit  >41 publications with Col3a1 and Col5a1
 Col5a2 elisa kit  >38 publications with Col3a1 and Col5a2
 Col4a1 elisa kit  >20 publications with Col3a1 and Col4a1
 Col6a3 elisa kit  >17 publications with Col3a1 and Col6a3
 Col6a1 elisa kit  >14 publications with Col3a1 and Col6a1
 Col6a2 elisa kit  >7 publications with Col3a1 and Col6a2
 Col16a1 elisa kit  >1 publications with Col3a1 and Col16a1
 Col8a1 elisa kit  >1 publications with Col3a1 and Col8a1
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
Diseases associated with Col3a1 elisa kitOrgans/Tissues associated with Col3a1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >216 publications with Col3a1 and Cardiovascular Diseases
 Ehlers-Danlos Syndrome Antibodies  >178 publications with Col3a1 and Ehlers-Danlos Syndrome
 Fibrosis Antibodies  >107 publications with Col3a1 and Fibrosis
 Inflammation Antibodies  >47 publications with Col3a1 and Inflammation
 Disease Models, Animal Antibodies  >45 publications with Col3a1 and Disease Models, Animal
 Heart Diseases Antibodies  >37 publications with Col3a1 and Heart Diseases
 Hypertension Antibodies  >19 publications with Col3a1 and Hypertension
 Necrosis Antibodies  >15 publications with Col3a1 and Necrosis
 Hypertrophy Antibodies  >13 publications with Col3a1 and Hypertrophy
 Liver Diseases Antibodies  >12 publications with Col3a1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >126 publications with Col3a1 and Connective Tissue
 Skin Antibodies  >121 publications with Col3a1 and Skin
 Other Antibodies  >107 publications with Col3a1 and Other
 Muscle Antibodies  >101 publications with Col3a1 and Muscle
 Artery Antibodies  >77 publications with Col3a1 and Artery
 Bone Antibodies  >56 publications with Col3a1 and Bone
 Joint Antibodies  >53 publications with Col3a1 and Joint
 Heart Antibodies  >48 publications with Col3a1 and Heart
 Lung Antibodies  >42 publications with Col3a1 and Lung
 Kidney Antibodies  >18 publications with Col3a1 and Kidney
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