NP_958850.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,684 Da
NCBI Official Full Name
complement C1s subcomponent
NCBI Official Synonym Full Names
complement component 1, s subcomponent
NCBI Protein Information
complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s
UniProt Protein Name
Complement C1s subcomponent
UniProt Synonym Protein Names
C1 esterase; Complement component 1 subcomponent sCleaved into the following 2 chains:Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain
UniProt Entry Name
C1S_HUMAN
NCBI Summary for C1S
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
UniProt Comments for C1S
C1S: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Defects in C1S are the cause of complement component C1s deficiency (C1SD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.42; Protease
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: extracellular region
Molecular Function: identical protein binding; protein binding; serine-type endopeptidase activity; calcium ion binding
Biological Process: innate immune response; proteolysis; complement activation, classical pathway; complement activation
Disease: Complement Component C1s Deficiency
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Pathways associated with C1S elisa kit
Diseases associated with C1S elisa kit
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