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Cubn elisa kit :: Mouse Cubilin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2881592
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $420 +1 FREE 8GB USB
96-Strip-Wells  /  $560 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,445 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,520 +5 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cubilin (Cubn), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Cubilin ELISA Kit

 Product Synonym Names    Cubilin; Intrinsic factor-cobalamin receptor; Cubn; Ifcr
 Product Gene Name   

Cubn elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2881592 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for Q9JLB4
 Species Reactivity    Mouse
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 Assay Type    Sandwich
 Detection Range    0.156-10 ng/mL
 Sensitivity    0.082 ng/mL
 Intra-Assay CV    <=4.9%
 Inter-Assay CV    <=6.4%
 Recovery    83%
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Cubn elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Cubn purchase    MBS2881592 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cubilin (Cubn) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10 ng/mL in biological research samples containing Cubn, with an estimated sensitivity of 0.082 ng/mL. The ELISA analytical biochemical technique of the MBS2881592 kit is based on Cubn antibody-Cubn antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Cubn antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Cubn. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for Cubn elisa kit

   Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of Cubn elisa kit    Cubn elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2881592. Click to request current manual
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NCBI/Uniprot data below describe general gene information for Cubn. It may not necessarily be applicable to this product.
 NCBI GI #    124487348
 NCBI GeneID    65969
 NCBI Accession #    NP_001074553.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081084.2 [Other Products]
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 UniProt Primary Accession #    Q9JLB4 [Other Products]
 UniProt Secondary Accession #    B1AX10 [Other Products]
 UniProt Related Accession #    Q9JLB4 [Other Products]
 Molecular Weight    399,097 Da
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 NCBI Official Full Name    cubilin
 NCBI Official Synonym Full Names    cubilin (intrinsic factor-cobalamin receptor)
 NCBI Official Symbol    Cubn [Similar Products]
 NCBI Official Synonym Symbols   
AA408369; AL022750; D2Wsu88e
[Similar Products]
 NCBI Protein Information    cubilin
 UniProt Protein Name    Cubilin
 UniProt Synonym Protein Names   
Intrinsic factor-cobalamin receptor
 Protein Family    Cubilin
 UniProt Gene Name    Cubn [Similar Products]
 UniProt Synonym Gene Names    Ifcr [Similar Products]
 UniProt Entry Name    CUBN_MOUSE
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 UniProt Comments for Cubn    CUBN: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Defects in CUBN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.

Cellular Component: apical part of cell; apical plasma membrane; brush border; brush border membrane; coated pit; cytoplasm; endocytic vesicle; endoplasmic reticulum; endosome; Golgi apparatus; lysosomal lumen; lysosome; membrane; protein complex

Molecular Function: calcium ion binding; cobalamin binding; cobalamin transporter activity; hemoglobin binding; identical protein binding; metal ion binding; protein binding; protein homodimerization activity; receptor activity

Biological Process: cholesterol metabolic process; cobalamin transport; hemoglobin import; in utero embryonic development; lipid metabolic process; lipoprotein transport; protein transport; receptor-mediated endocytosis; response to nutrient; steroid metabolic process; transport
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 Research Articles on Cubn    1. Cubilin deficiency reduces renal salvage and delivery back to the blood of albumin and apolipoprotein (apo)A-I, which decreases blood levels of albumin and apoA-I/HD
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cubn elisa kitPathways associated with Cubn elisa kit
 Reference Product  PubMed Publications
 Amn elisa kit  >21 publications with Cubn and Amn
 Gif elisa kit  >5 publications with Cubn and Gif
 Lrp2 elisa kit  >4 publications with Cubn and Lrp2
 Products by Pathway  Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram
Diseases associated with Cubn elisa kitOrgans/Tissues associated with Cubn elisa kit
 Disease Name  Pubmed Publications
 Proteinuria Antibodies  >27 publications with Cubn and Proteinuria
 Anemia Antibodies  >25 publications with Cubn and Anemia
 MEGALOBLASTIC ANEMIA 1 Antibodies  >18 publications with Cubn and MEGALOBLASTIC ANEMIA 1
 Kidney Diseases Antibodies  >5 publications with Cubn and Kidney Diseases
 Heart Diseases Antibodies  >5 publications with Cubn and Heart Diseases
 Congenital Abnormalities Antibodies  >5 publications with Cubn and Congenital Abnormalities
 Disease Models, Animal Antibodies  >4 publications with Cubn and Disease Models, Animal
 Renal Insufficiency Antibodies  >3 publications with Cubn and Renal Insufficiency
 Inflammation Antibodies  >2 publications with Cubn and Inflammation
 Hypertension Antibodies  >1 publications with Cubn and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >18 publications with Cubn and Kidney
 Embryonic Tissue Antibodies  >2 publications with Cubn and Embryonic Tissue
 Eye Antibodies  >1 publications with Cubn and Eye
 Brain Antibodies  >1 publications with Cubn and Brain
 Skin Antibodies  >1 publications with Cubn and Skin
 Liver Antibodies  >1 publications with Cubn and Liver
 Bone Marrow Antibodies  >1 publications with Cubn and Bone Marrow
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