NP_001288297.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
18,066 Da
NCBI Official Full Name
cyclin-dependent kinase 4 inhibitor C
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NCBI Official Synonym Symbols
p18; INK4c; C77269; p18-INK6; p18INK4c; p18-INK4c [Similar Products]
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor C
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor C
UniProt Synonym Protein Names
Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
UniProt Entry Name
CDN2C_MOUSE
NCBI Summary for Cdkn2c
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]
UniProt Comments for Cdkn2c
CDKN2C: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Protein type: Protein kinase, regulatory subunit; Cell cycle regulation; Inhibitor
Cellular Component: cytoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein kinase binding
Biological Process: cell cycle; cell cycle arrest; G1/S transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity
Research Articles on Cdkn2c
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Pathways associated with Cdkn2c elisa kit
Diseases associated with Cdkn2c elisa kit
Organs/Tissues associated with Cdkn2c elisa kit
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