NP_034000.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
33,751 Da
NCBI Official Full Name
cyclin-dependent kinase 4
NCBI Official Synonym Full Names
cyclin-dependent kinase 4
NCBI Official Synonym Symbols
NCBI Protein Information
cyclin-dependent kinase 4
UniProt Protein Name
Cyclin-dependent kinase 4
UniProt Synonym Protein Names
CRK3; Cell division protein kinase 4; PSK-J3
UniProt Synonym Gene Names
UniProt Entry Name
CDK4_MOUSE
UniProt Comments for Cdk4
CDK4: a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991.
Protein type: EC 2.7.11.22; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Cell cycle regulation; CMGC group; CDK family; CDK/CDK4 subfamily; CDK4 subfamily
Cellular Component: chromatin; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; nuclear membrane; nucleolus; nucleus; perinuclear region of cytoplasm; tight junction; transcription factor complex
Molecular Function: ATP binding; cyclin binding; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: cell cycle; cell division; G1/S transition of mitotic cell cycle; phosphorylation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of fibroblast proliferation; positive regulation of translation; protein amino acid phosphorylation; regulation of cell cycle; regulation of cell proliferation; regulation of gene expression; response to drug; response to lead ion; response to organic substance; response to testosterone stimulus; signal transduction
Research Articles on Cdk4
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Products associated with Cdk4 elisa kit
Pathways associated with Cdk4 elisa kit
Diseases associated with Cdk4 elisa kit
Organs/Tissues associated with Cdk4 elisa kit
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