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SLC7A11 elisa kit :: Mouse Cystine/glutamate transporter (SLC7A11) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7216383
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cystine/glutamate transporter (SLC7A11), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Cystine/glutamate transporter (SLC7A11) ELISA Kit

 Product Gene Name   

SLC7A11 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    607933
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of SLC7A11. No significant cross-reactivity or interference between SLC7A11 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between SLC7A11 and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Sensitivity    0.1 ng/mL.
 Intended Uses    This SLC7A11 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Mouse SLC7A11. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SLC7A11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SLC7A11 purchase    MBS7216383 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cystine/glutamate transporter (SLC7A11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC7A11, with an estimated sensitivity of 0.1 ng/mL. The ELISA analytical biochemical technique of the MBS7216383 kit is based on SLC7A11 antibody-SLC7A11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC7A11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC7A11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SLC7A11 elisa kit

  
Principle of the assay: SLC7A11 ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-SLC7A11 antibody and an SLC7A11-HRP conjugate. The assay sample and buffer are incubated together with SLC7A11-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the SLC7A11 concentration since SLC7A11 from samples and SLC7A11-HRP conjugate compete for the anti-SLC7A11 antibody binding site. Since the number of sites is limited, as more sites are occupied by SLC7A11 from the sample, fewer sites are left to bind SLC7A11-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The SLC7A11 concentration in each sample is interpolated from this standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of SLC7A11 elisa kit    SLC7A11 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS7216383. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SLC7A11. It may not necessarily be applicable to this product.
 NCBI GI #    7657683
 NCBI GeneID    23657
 NCBI Accession #    NP_055146.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014331.3 [Other Products]
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 UniProt Secondary Accession #    A8K2U4 [Other Products]
 UniProt Related Accession #    Q9UPY5 [Other Products]
 Molecular Weight    55,423 Da
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 NCBI Official Full Name    cystine/glutamate transporter
 NCBI Official Synonym Full Names    solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
 NCBI Official Symbol    SLC7A11 [Similar Products]
 NCBI Official Synonym Symbols   
xCT; CCBR1
[Similar Products]
 NCBI Protein Information    cystine/glutamate transporter; amino acid transport system xc-; solute carrier family 7 member 11; calcium channel blocker resistance protein CCBR1; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
 UniProt Protein Name    Cystine/glutamate transporter
 UniProt Synonym Protein Names   
Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
 Protein Family    Cystine/glutamate transporter
 UniProt Gene Name    SLC7A11 [Similar Products]
 UniProt Entry Name    XCT_HUMAN
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 NCBI Summary for SLC7A11    This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
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 UniProt Comments for SLC7A11    SLC7A11: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 4q28.3

Cellular Component: cytoskeleton; cell surface; rough endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: protein binding; cystine:glutamate antiporter activity

Biological Process: response to nicotine; amino acid transport; response to toxin; ion transport; response to oxidative stress; brain development; blood coagulation; leukocyte migration; transmembrane transport
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 Research Articles on SLC7A11    1. IGF-I regulates cystine uptake and cellular redox status by activating the expression and function of xCT in estrogen receptor-positive (ER(+)) breast cancer cells by a mechanism that relies on the IGF receptor substrate-1 (IRS-1).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SLC7A11 elisa kitPathways associated with SLC7A11 elisa kit
 Reference Product  PubMed Publications
 SLC3A2 elisa kit  >6 publications with SLC7A11 and SLC3A2
 CD44 elisa kit  >5 publications with SLC7A11 and CD44
 TRIB3 elisa kit  >2 publications with SLC7A11 and TRIB3
 ASNS elisa kit  >2 publications with SLC7A11 and ASNS
 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with SLC7A11 elisa kitOrgans/Tissues associated with SLC7A11 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >24 publications with SLC7A11 and Nervous System Diseases
 Brain Diseases Antibodies  >21 publications with SLC7A11 and Brain Diseases
 Inflammation Antibodies  >7 publications with SLC7A11 and Inflammation
 Lung Neoplasms Antibodies  >6 publications with SLC7A11 and Lung Neoplasms
 Breast Neoplasms Antibodies  >6 publications with SLC7A11 and Breast Neoplasms
 Lung Diseases Antibodies  >5 publications with SLC7A11 and Lung Diseases
 Neoplasms, Experimental Antibodies  >5 publications with SLC7A11 and Neoplasms, Experimental
 Liver Diseases Antibodies  >5 publications with SLC7A11 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with SLC7A11 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >4 publications with SLC7A11 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >47 publications with SLC7A11 and Brain
 Blood Antibodies  >16 publications with SLC7A11 and Blood
 Eye Antibodies  >11 publications with SLC7A11 and Eye
 Lung Antibodies  >8 publications with SLC7A11 and Lung
 Vascular Antibodies  >5 publications with SLC7A11 and Vascular
 Kidney Antibodies  >5 publications with SLC7A11 and Kidney
 Liver Antibodies  >5 publications with SLC7A11 and Liver
 Pancreas Antibodies  >5 publications with SLC7A11 and Pancreas
 Skin Antibodies  >5 publications with SLC7A11 and Skin
 Stomach Antibodies  >4 publications with SLC7A11 and Stomach
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