EAW86811.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,661 Da
NCBI Official Full Name
cytochrome P450, family 7, subfamily A, polypeptide 1
NCBI Official Synonym Full Names
cytochrome P450, family 7, subfamily A, polypeptide 1
NCBI Protein Information
cholesterol 7-alpha-monooxygenase; cytochrome P450 7A1; cholesterol 7-alpha-hydroxylase; cytochrome P450, subfamily VIIA polypeptide 1
UniProt Protein Name
Cholesterol 7-alpha-monooxygenase
UniProt Synonym Protein Names
CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1
UniProt Synonym Gene Names
UniProt Entry Name
CP7A1_HUMAN
NCBI Summary for CYP7A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
UniProt Comments for CYP7A1
CYP7A1: Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. Belongs to the cytochrome P450 family.
Protein type: EC 1.14.13.17; Endoplasmic reticulum; Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis
Chromosomal Location of Human Ortholog: 8q11-q12
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: cholesterol 7-alpha-monooxygenase activity; iron ion binding; heme binding
Biological Process: bile acid biosynthetic process; cholesterol homeostasis; bile acid metabolic process; xenobiotic metabolic process; cellular lipid metabolic process; cholesterol catabolic process; sterol metabolic process; transmembrane transport
Research Articles on CYP7A1
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Products associated with CYP7A1 elisa kit
Pathways associated with CYP7A1 elisa kit
Diseases associated with CYP7A1 elisa kit
Organs/Tissues associated with CYP7A1 elisa kit
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