NP_031896.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,760 Da
NCBI Official Full Name
deoxyribonuclease gamma
NCBI Official Synonym Full Names
deoxyribonuclease 1-like 3
NCBI Protein Information
deoxyribonuclease gamma
UniProt Protein Name
Deoxyribonuclease gamma
UniProt Synonym Protein Names
DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD
UniProt Synonym Gene Names
UniProt Comments for DNASE1L3
DNASE1L3: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units. Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16). A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Belongs to the DNase I family.
Protein type: Apoptosis; Calcium-binding; Deoxyribonuclease; EC 3.1.21.-; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14|14 A1
Cellular Component: endoplasmic reticulum; extracellular region; nucleus
Molecular Function: deoxyribonuclease activity; DNA binding; endodeoxyribonuclease activity; endonuclease activity; hydrolase activity; nuclease activity
Biological Process: apoptosis; apoptotic DNA fragmentation; DNA catabolic process; programmed cell death
Research Articles on DNASE1L3
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Diseases associated with DNASE1L3 elisa kit
Organs/Tissues associated with DNASE1L3 elisa kit
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