NP_112451.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
222,268 Da
NCBI Official Full Name
Down syndrome cell adhesion molecule homolog
NCBI Official Synonym Full Names
Down syndrome cell adhesion molecule
NCBI Protein Information
Down syndrome cell adhesion molecule homolog
UniProt Protein Name
Down syndrome cell adhesion molecule homolog
UniProt Entry Name
DSCAM_MOUSE
UniProt Comments for DSCAM
DSCAM: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Cellular Component: growth cone; membrane; axon; integral to membrane; plasma membrane
Molecular Function: protein binding
Biological Process: nervous system development; post-embryonic retina morphogenesis in camera-type eye; dendrite morphogenesis; positive regulation of axon extension involved in axon guidance; locomotory behavior; negative regulation of cell adhesion; cell adhesion; positive regulation of phosphorylation
Research Articles on DSCAM
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Pathways associated with DSCAM elisa kit
Diseases associated with DSCAM elisa kit
Organs/Tissues associated with DSCAM elisa kit
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