NP_064550.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,223 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase RAD18
NCBI Official Synonym Full Names
RAD18 E3 ubiquitin protein ligase
NCBI Official Synonym Symbols
NCBI Protein Information
E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18 homolog; RING finger protein 73; RAD18, S. cerevisiae, homolog; postreplication repair protein RAD18; postreplication repair protein hRAD18p
UniProt Protein Name
E3 ubiquitin-protein ligase RAD18
UniProt Synonym Protein Names
Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73
UniProt Synonym Gene Names
UniProt Entry Name
RAD18_HUMAN
NCBI Summary for RAD18
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
UniProt Comments for RAD18
RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase; Ligase; DNA repair, damage; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: XY body; replication fork; nucleus; chromatin
Molecular Function: Y-form DNA binding; protein binding; zinc ion binding; ubiquitin protein ligase binding; damaged DNA binding; polyubiquitin binding; ligase activity
Biological Process: negative regulation of DNA recombination; protein ubiquitination; spermatogenesis; DNA repair; response to UV
Research Articles on RAD18
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Products associated with RAD18 elisa kit
Diseases associated with RAD18 elisa kit
Organs/Tissues associated with RAD18 elisa kit
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