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EGR2 elisa kit :: Mouse EGR2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2507387
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EGR2, ELISA Kit

★Popular Item★
 Also Known As   

Mouse EGR2 (Early Growth Response Protein 2) ELISA Kit

 Product Gene Name   

EGR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    129010
 3D Structure    ModBase 3D Structure for P11161
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Mouse EGR2. No significant cross-reactivity or interference between Mouse EGR2 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse EGR2 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.313--20ng/mL
 Sensitivity    0.188ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of EGR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EGR2 purchase    MBS2507387 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the EGR2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.313--20ng/mL in biological research samples containing EGR2, with an estimated sensitivity of 0.188ng/mL. The ELISA analytical biochemical technique of the MBS2507387 kit is based on EGR2 antibody-EGR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EGR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EGR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for EGR2 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of EGR2 in Mouse serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse EGR2. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse EGR2 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse EGR2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse EGR2. You can calculate the concentration of Mouse EGR2 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of EGR2 elisa kit    EGR2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2507387. Click to request current manual
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NCBI/Uniprot data below describe general gene information for EGR2. It may not necessarily be applicable to this product.
 NCBI GI #    9845524
 NCBI GeneID    1959
 NCBI Accession #    NP_000390.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000399.3 [Other Products]
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 UniProt Primary Accession #    P11161 [Other Products]
 UniProt Secondary Accession #    Q68CZ5; Q8IV26; Q9UNA6; B2R724; B3KRD7 [Other Products]
 UniProt Related Accession #    P11161 [Other Products]
 Molecular Weight    44,970 Da
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 NCBI Official Full Name    E3 SUMO-protein ligase EGR2 isoform a
 NCBI Official Synonym Full Names    early growth response 2
 NCBI Official Symbol    EGR2 [Similar Products]
 NCBI Official Synonym Symbols   
AT591; CMT1D; CMT4E; KROX20
[Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase EGR2; KROX-20, Drosophila, homolog (early growth response-2); early growth response protein 2; zinc finger protein Krox-20
 UniProt Protein Name    E3 SUMO-protein ligase EGR2
 UniProt Synonym Protein Names   
AT591; Early growth response protein 2; EGR-2; Zinc finger protein Krox-20
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    EGR2 [Similar Products]
 UniProt Synonym Gene Names    KROX20; EGR-2 [Similar Products]
 UniProt Entry Name    EGR2_HUMAN
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 NCBI Summary for EGR2    The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for EGR2    EGR2: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN). Inheritance can be autosomal dominant or recessive. Recessive CHN is also known as Charcot- Marie-Tooth disease type 4E (CMT4E). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities. Defects in EGR2 are a cause of Charcot-Marie-Tooth disease type 1D (CMT1D). CMT1D is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. Defects in EGR2 are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the EGR C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding; metal ion binding; chromatin binding; transcription factor activity; ligase activity

Biological Process: myelination; fat cell differentiation; transcription from RNA polymerase II promoter; facial nerve structural organization; rhombomere 5 formation; positive regulation of transcription, DNA-dependent; motor axon guidance; response to insulin stimulus; peripheral nervous system development; Schwann cell differentiation; rhythmic behavior; protein sumoylation; learning and/or memory; rhombomere 3 formation; positive regulation of transcription from RNA polymerase II promoter; brain development; protein export from nucleus; regulation of ossification; brain segmentation; negative regulation of apoptosis; regulation of neuronal synaptic plasticity

Disease: Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive; Hypertrophic Neuropathy Of Dejerine-sottas; Charcot-marie-tooth Disease, Demyelinating, Type 1d
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 Research Articles on EGR2    1. transcription factor early growth response gene-2 is a novel molecular switch regulating known immunomodulatory molecules in human mesenchymal stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EGR2 elisa kitPathways associated with EGR2 elisa kit
 Reference Product  PubMed Publications
 MPZ elisa kit  >58 publications with EGR2 and MPZ
 SOX10 elisa kit  >31 publications with EGR2 and SOX10
 PRX elisa kit  >16 publications with EGR2 and PRX
 NFATC1 elisa kit  >3 publications with EGR2 and NFATC1
 STAT6 elisa kit  >2 publications with EGR2 and STAT6
 NFATC3 elisa kit  >2 publications with EGR2 and NFATC3
 CREBBP elisa kit  >2 publications with EGR2 and CREBBP
 RELA elisa kit  >1 publications with EGR2 and RELA
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 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram
Diseases associated with EGR2 elisa kitOrgans/Tissues associated with EGR2 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >144 publications with EGR2 and Nervous System Diseases
 Hereditary Sensory and Motor Neuropathy Antibodies  >73 publications with EGR2 and Hereditary Sensory and Motor Neuropathy
 Brain Diseases Antibodies  >30 publications with EGR2 and Brain Diseases
 Disease Models, Animal Antibodies  >25 publications with EGR2 and Disease Models, Animal
 Inflammation Antibodies  >19 publications with EGR2 and Inflammation
 Nerve Degeneration Antibodies  >10 publications with EGR2 and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >9 publications with EGR2 and Cardiovascular Diseases
 Seizures Antibodies  >8 publications with EGR2 and Seizures
 Abnormalities, Drug-Induced Antibodies  >7 publications with EGR2 and Abnormalities, Drug-Induced
 Necrosis Antibodies  >6 publications with EGR2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >192 publications with EGR2 and Nerve
 Brain Antibodies  >182 publications with EGR2 and Brain
 Blood Antibodies  >95 publications with EGR2 and Blood
 Embryonic Tissue Antibodies  >34 publications with EGR2 and Embryonic Tissue
 Bone Antibodies  >31 publications with EGR2 and Bone
 Ganglia Antibodies  >20 publications with EGR2 and Ganglia
 Lung Antibodies  >15 publications with EGR2 and Lung
 Connective Tissue Antibodies  >13 publications with EGR2 and Connective Tissue
 Skin Antibodies  >12 publications with EGR2 and Skin
 Thymus Antibodies  >11 publications with EGR2 and Thymus
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