NP_034274.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,848 Da
NCBI Official Full Name
ephrin type-B receptor 4 isoform b
NCBI Official Synonym Full Names
Eph receptor B4
NCBI Official Synonym Symbols
Htk; MDK2; Myk1; Tyro11; AI042935 [Similar Products]
NCBI Protein Information
ephrin type-B receptor 4; mDK-2; tyrosine kinase MYK-1; developmental kinase 2; hepatoma transmembrane kinase
UniProt Protein Name
Ephrin type-B receptor 4
UniProt Synonym Protein Names
Developmental kinase 2; mDK-2; Hepatoma transmembrane kinase; Tyrosine kinase MYK-1
UniProt Synonym Gene Names
UniProt Entry Name
EPHB4_MOUSE
UniProt Comments for EPHB4
EphB4: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; Kinase, protein; TK group; Eph family
Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity
Biological Process: heart morphogenesis; peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; multicellular organismal development; protein amino acid autophosphorylation; ephrin receptor signaling pathway; angiogenesis; cell adhesion; phosphorylation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on EPHB4
Precautions
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Pathways associated with EPHB4 elisa kit
Diseases associated with EPHB4 elisa kit
Organs/Tissues associated with EPHB4 elisa kit
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