P22387.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,809 Da
NCBI Official Full Name
Endothelin-1
NCBI Official Synonym Full Names
endothelin 1
NCBI Protein Information
endothelin-1; PPET1; preproendothelin; preproendothelin-1
UniProt Protein Name
Endothelin-1
UniProt Synonym Protein Names
Preproendothelin-1; PPET1
UniProt Synonym Gene Names
UniProt Entry Name
EDN1_MOUSE
UniProt Comments for EDN1
EDN1: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; cell; cytoplasm; extracellular region; cytosol
Molecular Function: protein binding; hormone activity; endothelin B receptor binding; cytokine activity; endothelin A receptor binding; receptor binding
Biological Process: positive regulation of JNK activity; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of systemic arterial blood pressure by endothelin; heart development; middle ear morphogenesis; prostaglandin biosynthetic process; sensory perception of pain; positive regulation of MAP kinase activity; negative regulation of cAMP biosynthetic process; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; negative regulation of nitric-oxide synthase biosynthetic process; protein kinase C activation; regulation of blood vessel size; cell growth; rhythmic excitation; positive regulation of mitosis; positive regulation of heart rate; respiratory gaseous exchange; peptide hormone secretion; patterning of blood vessels; membrane depolarization; protein kinase C deactivation; regulation of vasoconstriction; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; superoxide release; positive regulation of odontogenesis; epithelial fluid transport; phosphoinositide 3-kinase cascade; positive regulation of cell size; neural crest cell development; G-protein signaling, phospholipase D activating pathway; positive regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; negative regulation of cellular protein metabolic process; negative regulation of transcription from RNA polymerase II promoter; glucose transport; vein smooth muscle contraction; histamine secretion; nitric oxide transport; regulation of blood pressure; positive regulation of cell proliferation; regulation of pH; positive regulation of smooth muscle contraction; skeletal development; artery smooth muscle contraction; vasoconstriction; inositol phosphate-mediated signaling; in utero embryonic development; calcium-mediated signaling; positive regulation of hormone secretion; body fluid secretion; G-protein coupled receptor protein signaling pathway; dorsal/ventral pattern formation; cartilage development; positive regulation of prostaglandin secretion; response to hypoxia; regulation of sensory perception of pain; positive regulation of cell migration
Research Articles on EDN1
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Pathways associated with EDN1 elisa kit
Diseases associated with EDN1 elisa kit
Organs/Tissues associated with EDN1 elisa kit
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