NP_005411.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,126 Da
NCBI Official Full Name
estrogen sulfotransferase
NCBI Official Synonym Full Names
sulfotransferase family 1E, estrogen-preferring, member 1
NCBI Protein Information
estrogen sulfotransferase; sulfotransferase 1E1; estrone sulfotransferase; sulfotransferase, estrogen-preferring
UniProt Protein Name
Estrogen sulfotransferase
UniProt Synonym Protein Names
EST-1; Sulfotransferase 1E1; ST1E1; Sulfotransferase, estrogen-preferring
UniProt Synonym Gene Names
UniProt Entry Name
ST1E1_HUMAN
NCBI Summary for E1S
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for E1S
SULT1E1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. Belongs to the sulfotransferase 1 family.
Protein type: Lipid Metabolism - androgen and estrogen; EC 2.8.2.4; Energy Metabolism - sulfur; Transferase
Chromosomal Location of Human Ortholog: 4q13.1
Cellular Component: cytosol
Molecular Function: steroid sulfotransferase activity; estrone sulfotransferase activity; flavonol 3-sulfotransferase activity; steroid binding
Biological Process: steroid metabolic process; estrogen metabolic process; xenobiotic metabolic process; sulfation; female pregnancy; 3'-phosphoadenosine 5'-phosphosulfate metabolic process
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Products associated with E1S elisa kit
Pathways associated with E1S elisa kit
Diseases associated with E1S elisa kit
Organs/Tissues associated with E1S elisa kit
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