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FOLR1 elisa kit :: Mouse FOLR1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS177151
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $425 +1 FREE 8GB USB
 
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 Product Name   

FOLR1, ELISA Kit

★Popular Item★
 Also Known As   

Mouse FOLR1 PicoKine ELISA Kit

 Product Synonym Names    Folate receptor alpha; folate receptor 1 (adult); Adult folate binding protein; Adult folate-binding protein; FBP; Folate Receptor 1 Adult; Folate receptor 1; Folate Receptor 1 Precursor; Folate receptor adult; Folate receptor alpha; Folate receptor; FOLR; FOLR1; FOLR1_HUMAN; FR alpha; FR-alpha; FRalpha; KB cells FBP; MOV18; Ovarian cancer associated antigen; Ovarian tumor associated antigen; Ovarian tumor associated antigen MOv18; Ovarian tumor-associated antigen MOv18
 Product Gene Name   

FOLR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P35846
 Species Reactivity    Mouse
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 Specificity    Natural and recombinant mouse FOLR1
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 Samples    Cell culture supernates, cell Iysates, tissue homo~lenates, serum and plasma (heparin, EDTA)
 Assay Type    Quantitative Sandwich
 Detection Range    46.9pg/ml-3000pg/ml
 Sensitivity    < 10pg/ml
 Intra-assay Precision    Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
 Inter-assay Precision    Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FOLR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FOLR1 purchase    MBS177151 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the FOLR1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 46.9pg/ml-3000pg/ml in biological research samples containing FOLR1, with an estimated sensitivity of < 10pg/ml. The ELISA analytical biochemical technique of the MBS177151 kit is based on FOLR1 antibody-FOLR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FOLR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FOLR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, cell Iysates, tissue homo~lenates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FOLR1 elisa kit

   Principle of the Assay: The mouse FOLR1 EliSA Kit was based on standard sandwich en'<:'1me-linked immune-sorbent assay technology. A monoclonal aniibody from rat specific for FOLR 1 has been precoated onto 96-well plates. Standards (Expression system for standard: E.coli, Immunogen sequence: T25-S232) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for FOLR1 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the mouse FOLR1 amount of sample captured in plate.

Background/Introduction: Folate receptor 1 adult is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor(FOLR) family. It is mapped to 11q13.4. FOLR1 expression in Jurkat cells facilitated MBG or EBO entry, and FR-blocking reagents inhibited infection of MBG or EBO. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. The FOLR1 gene encodes the adult folate receptor, or folate-binding protein(FBP), which has a high affinity for folic acid and for several reduced folic acid derivatives, and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is also an important regulator of milk protein synthesis.
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 Typical Testing Data/Standard Curve (for reference only) of FOLR1 elisa kit    Mouse FOLR1 PicoKine ELISA Kit standard curve
FOLR1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS177151. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FOLR1. It may not necessarily be applicable to this product.
 NCBI GI #    565683203
 NCBI GeneID    14275
 NCBI Accession #    P35846.2 [Other Products]
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 UniProt Primary Accession #    P35846 [Other Products]
 UniProt Secondary Accession #    Q9R222 [Other Products]
 UniProt Related Accession #    P35846 [Other Products]
 Molecular Weight    29,449 Da
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 NCBI Official Full Name    Folate receptor alpha
 NCBI Official Synonym Full Names    folate receptor 1 (adult)
 NCBI Official Symbol    Folr1 [Similar Products]
 NCBI Official Synonym Symbols   
FBP1; Folbp1; Folbp-1
[Similar Products]
 NCBI Protein Information    folate receptor alpha; FR-alpha; folate binding protein 1; folate-binding protein 1
 UniProt Protein Name    Folate receptor alpha
 UniProt Synonym Protein Names   
Folate receptor 1; Folate-binding protein 1
 Protein Family    Folate receptor
 UniProt Gene Name    Folr1 [Similar Products]
 UniProt Synonym Gene Names    Fbp1; Folbp1; FR-alpha [Similar Products]
 UniProt Entry Name    FOLR1_MOUSE
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 UniProt Comments for FOLR1    FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.

Protein type: Membrane protein, GPI anchor

Cellular Component: anchored to external side of plasma membrane; anchored to plasma membrane; cell surface; membrane; cell; brush border membrane; extracellular region; plasma membrane; intracellular; cytoplasmic vesicle; brush border; endosome

Molecular Function: folic acid transporter activity; receptor activity; folic acid binding

Biological Process: transport; folic acid metabolic process; posttranslational protein targeting to membrane; folic acid transport
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 Research Articles on FOLR1    1. Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with FOLR1 elisa kitDiseases associated with FOLR1 elisa kit
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >38 publications with FOLR1 and Ovarian Neoplasms
 Nervous System Diseases Antibodies  >32 publications with FOLR1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >24 publications with FOLR1 and Adenocarcinoma
 Neural Tube Defects Antibodies  >21 publications with FOLR1 and Neural Tube Defects
 Brain Diseases Antibodies  >20 publications with FOLR1 and Brain Diseases
 Congenital Abnormalities Antibodies  >20 publications with FOLR1 and Congenital Abnormalities
 Nervous System Malformations Antibodies  >13 publications with FOLR1 and Nervous System Malformations
 Neoplasms, Experimental Antibodies  >9 publications with FOLR1 and Neoplasms, Experimental
 Epilepsy Antibodies  >8 publications with FOLR1 and Epilepsy
 Disease Models, Animal Antibodies  >7 publications with FOLR1 and Disease Models, Animal
Organs/Tissues associated with FOLR1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with FOLR1 and Blood
 Lung Antibodies  >24 publications with FOLR1 and Lung
 Brain Antibodies  >21 publications with FOLR1 and Brain
 Intestine Antibodies  >6 publications with FOLR1 and Intestine
 Embryonic Tissue Antibodies  >6 publications with FOLR1 and Embryonic Tissue
 Eye Antibodies  >4 publications with FOLR1 and Eye
 Thyroid Antibodies  >3 publications with FOLR1 and Thyroid
 Mammary Gland Antibodies  >3 publications with FOLR1 and Mammary Gland
 Kidney Antibodies  >3 publications with FOLR1 and Kidney
 Oviduct Antibodies  >1 publications with FOLR1 and Oviduct
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