NP_034337.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,531 Da
NCBI Official Full Name
fibroblast growth factor receptor 2 isoform IIIc
NCBI Official Synonym Full Names
fibroblast growth factor receptor 2
NCBI Official Synonym Symbols
Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; KGFRTr; AU043015; AW556123 [Similar Products]
NCBI Protein Information
fibroblast growth factor receptor 2
UniProt Protein Name
Fibroblast growth factor receptor 2
UniProt Synonym Protein Names
Keratinocyte growth factor receptor; KGFR; CD_antigen: CD332
UniProt Synonym Gene Names
UniProt Comments for FGFR2
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Research Articles on FGFR2
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Pathways associated with FGFR2 elisa kit
Diseases associated with FGFR2 elisa kit
Organs/Tissues associated with FGFR2 elisa kit
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