NP_001091671.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,248 Da
NCBI Official Full Name
G-protein coupled estrogen receptor 1
NCBI Official Synonym Full Names
G protein-coupled estrogen receptor 1
NCBI Official Synonym Symbols
mER; CEPR; GPER; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br [Similar Products]
NCBI Protein Information
G-protein coupled estrogen receptor 1
UniProt Protein Name
G-protein coupled estrogen receptor 1
UniProt Synonym Protein Names
Chemoattractant receptor-like 2; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; G protein-coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; IL8-related receptor DRY12; Lymphocyte-derived G-protein coupled receptor; LYGPR; Membrane estrogen receptor; mER
UniProt Synonym Gene Names
UniProt Entry Name
GPER1_HUMAN
NCBI Summary for GPER
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for GPER
GPER1: Receptor for estrogen. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 1
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component: Golgi apparatus; integral to plasma membrane; dendrite; early endosome; nuclear envelope; trans-Golgi network; recycling endosome; perinuclear region of cytoplasm; keratin filament; cytoplasm; dendritic shaft; intracellular; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; endoplasmic reticulum; postsynaptic density; Golgi membrane; presynaptic membrane; axon; mitochondrial membrane; plasma membrane; presynaptic active zone; nerve terminal; cell junction; nucleus
Molecular Function: G-protein coupled receptor activity; protein binding; estrogen receptor activity; chromatin binding; mineralocorticoid receptor activity; steroid binding
Biological Process: positive regulation of apoptosis; generation of action potential; nuclear fragmentation during apoptosis; positive regulation of caspase activity; positive regulation of vasodilation; negative regulation of DNA metabolic process; positive regulation of neurotransmitter secretion; negative regulation of leukocyte activation; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; inflammatory response; steroid hormone receptor signaling pathway; positive regulation of neurogenesis; cytosolic calcium ion homeostasis; negative regulation of lipid biosynthetic process; positive regulation of insulin secretion; positive regulation of inositol trisphosphate biosynthetic process; apoptotic chromosome condensation; negative regulation of fat cell differentiation; cell cycle; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; mineralocorticoid receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; negative regulation of inflammatory response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cell migration
Research Articles on GPER
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Pathways associated with GPER elisa kit
Diseases associated with GPER elisa kit
Organs/Tissues associated with GPER elisa kit
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