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GJb1 elisa kit :: Mouse GJb1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2511752
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   

Mouse GJb1 (Gap Junction Protein Beta 1) ELISA Kit

 Product Gene Name   

GJb1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    145900
 3D Structure    ModBase 3D Structure for P08034
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 Species Reactivity    Mouse
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 Specificity    This kit recognizes natural and recombinant Mouse GJb1. No significant cross-reactivity or interference between Mouse GJb1 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.781-50ng/mL
 Sensitivity    Min: 0.469ng/mL; Max: 50ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GJb1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GJb1 purchase    MBS2511752 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GJb1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.781-50ng/mL in biological research samples containing GJb1, with an estimated sensitivity of Min: 0.469ng/mL; Max: 50ng/mL. The ELISA analytical biochemical technique of the MBS2511752 kit is based on GJb1 antibody-GJb1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GJb1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GJb1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GJb1 elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Mouse GJb1 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to GJb1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for GJb1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain GJb1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of GJb1. You can calculate the concentration of GJb1 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of GJb1 elisa kit    GJb1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2511752. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GJb1. It may not necessarily be applicable to this product.
 NCBI GI #    148233402
 NCBI GeneID    2705
 NCBI Accession #    NP_001091111.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001097642.2 [Other Products]
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 UniProt Primary Accession #    P08034 [Other Products]
 UniProt Secondary Accession #    Q5U0S4; B2R8R2; D3DVV2 [Other Products]
 UniProt Related Accession #    P08034 [Other Products]
 Molecular Weight    32,025 Da
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 NCBI Official Full Name    gap junction beta-1 protein
 NCBI Official Synonym Full Names    gap junction protein, beta 1, 32kDa
 NCBI Official Symbol    GJB1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    gap junction beta-1 protein; GAP junction 28 kDa liver protein; connexin 32; connexin-32
 UniProt Protein Name    Gap junction beta-1 protein
 UniProt Synonym Protein Names   
Connexin-32; Cx32; GAP junction 28 kDa liver protein
 Protein Family    Gap junction beta-1 protein
 UniProt Gene Name    GJB1 [Similar Products]
 UniProt Synonym Gene Names    CX32; Cx32 [Similar Products]
 UniProt Entry Name    CXB1_HUMAN
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 NCBI Summary for GJb1    This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for GJb1    GJB1: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJB1 are the cause of Charcot-Marie-Tooth disease X-linked type 1 (CMTX1); also designated CMT- X. CMTX1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot- Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. CMTX1 has both demyelinating and axonal features. Central nervous system involvement may occur. Defects in GJB1 may contribute to the phenotype of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine- Sottas syndrome. Belongs to the connexin family. Beta-type (group I) subfamily.

Protein type: Motility/polarity/chemotaxis; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: connexon complex; endoplasmic reticulum membrane; integral to membrane

Molecular Function: protein homodimerization activity

Biological Process: nervous system development; cell-cell signaling; gap junction assembly; transport

Disease: Charcot-marie-tooth Disease, X-linked Dominant, 1
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 Research Articles on GJb1    1. This study reported four novel mutations, c.191G > A, c.508G > T, c.778A > G and c.300C > G of GJB1 in four Greek families with variable clinical features and mild clinical CNS manifestations in three of them.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GJb1 elisa kitPathways associated with GJb1 elisa kit
 Reference Product  PubMed Publications
 MPZ elisa kit  >53 publications with GJb1 and MPZ
 PMP22 elisa kit  >51 publications with GJb1 and PMP22
 EGR2 elisa kit  >24 publications with GJb1 and EGR2
 GJA1 elisa kit  >15 publications with GJb1 and GJA1
 GJB2 elisa kit  >14 publications with GJb1 and GJB2
 SOX10 elisa kit  >8 publications with GJb1 and SOX10
 GJD3 elisa kit  >1 publications with GJb1 and GJD3
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Gap Junction Assembly Pathway antibodies  Gap Junction Assembly Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Oligomerization Of Connexins Into Connexons Pathway antibodies  Oligomerization Of Connexins Into Connexons Pathway Diagram
 Transport Of Connexins Along The Secretory Pathway antibodies  Transport Of Connexins Along The Secretory Pathway Diagram
Diseases associated with GJb1 elisa kitOrgans/Tissues associated with GJb1 elisa kit
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >13 publications with GJb1 and Brain Diseases
 Charcot-Marie-Tooth disease, X-linked, 1 Antibodies  >10 publications with GJb1 and Charcot-Marie-Tooth disease, X-linked, 1
 Disease Models, Animal Antibodies  >6 publications with GJb1 and Disease Models, Animal
 Edema Antibodies  >2 publications with GJb1 and Edema
 Inflammation Antibodies  >2 publications with GJb1 and Inflammation
 Neoplasms, Experimental Antibodies  >1 publications with GJb1 and Neoplasms, Experimental
 Urinary Bladder Neoplasms Antibodies  >1 publications with GJb1 and Urinary Bladder Neoplasms
 Liver Diseases Antibodies  >1 publications with GJb1 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with GJb1 and Fatty Liver
 Infertility, Male Antibodies  >1 publications with GJb1 and Infertility, Male
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with GJb1 and Brain
 Liver Antibodies  >5 publications with GJb1 and Liver
 Heart Antibodies  >2 publications with GJb1 and Heart
 Mammary Gland Antibodies  >2 publications with GJb1 and Mammary Gland
 Skin Antibodies  >2 publications with GJb1 and Skin
 Embryonic Tissue Antibodies  >1 publications with GJb1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with GJb1 and Pancreas
 Kidney Antibodies  >1 publications with GJb1 and Kidney
 Testis Antibodies  >1 publications with GJb1 and Testis
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