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gp130 elisa kit :: Mouse Glucoprotein 130 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS733275
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucoprotein 130 (gp130), ELISA Kit

 Also Known As   

Mouse Glucoprotein 130 ELISA Kit

 Product Gene Name   

gp130 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600694
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 Species Reactivity    Mouse
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    10-250ng/mL
 Sensitivity    1.0ng/mL
 Highest Standards    250 ng/mL
 Concentration of Standards    Concentration of Standards
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of gp130 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for gp130 purchase    MBS733275 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glucoprotein 130 (gp130) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10-250ng/mL in biological research samples containing gp130, with an estimated sensitivity of 1.0ng/mL. The ELISA analytical biochemical technique of the MBS733275 kit is based on gp130 antibody-gp130 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect gp130 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, gp130. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for gp130 elisa kit    Cell Biology
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 Typical Testing Data/Standard Curve (for reference only) of gp130 elisa kit    gp130 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS733275. Click to request current manual
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NCBI/Uniprot data below describe general gene information for gp130. It may not necessarily be applicable to this product.
 NCBI GI #    1246098
 NCBI GeneID    3572
 NCBI Accession #    AAB35921.1 [Other Products]
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 UniProt Secondary Accession #    Q5FC04; Q9UQ41; A0N0L4 [Other Products]
 UniProt Related Accession #    P40189 [Other Products]
 Molecular Weight    96,276 Da
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 NCBI Official Full Name    gp130, partial
 NCBI Official Synonym Full Names    interleukin 6 signal transducer
 NCBI Official Symbol    IL6ST [Similar Products]
 NCBI Official Synonym Symbols   
CD130; GP130; CDW130; IL-6RB
[Similar Products]
 NCBI Protein Information    interleukin-6 receptor subunit beta; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; gp130, oncostatin M receptor; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
 UniProt Protein Name    Interleukin-6 receptor subunit beta
 UniProt Synonym Protein Names   
CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
 UniProt Gene Name    IL6ST [Similar Products]
 UniProt Synonym Gene Names    IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130 [Similar Products]
 UniProt Entry Name    IL6RB_HUMAN
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 NCBI Summary for gp130    The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
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 UniProt Comments for gp130    gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; extracellular region; plasma membrane; interleukin-6 receptor complex; external side of plasma membrane

Molecular Function: interleukin-11 binding; interleukin-27 receptor activity; protein homodimerization activity; oncostatin-M receptor activity; leukemia inhibitory factor receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 binding; interleukin-6 receptor binding; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: glycogen metabolic process; viral reproduction; leukemia inhibitory factor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; negative regulation of apoptosis
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 Research Articles on gp130    1. postulate that dynamic properties of the IL-6 AB-loop are responsible for inhibiting the interaction of IL-6 with gp130 in the absence of the IL-6R
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with gp130 elisa kitPathways associated with gp130 elisa kit
 Reference Product  PubMed Publications
 STAT3 elisa kit  >281 publications with gp130 and STAT3
 LIF elisa kit  >237 publications with gp130 and LIF
 OSM elisa kit  >178 publications with gp130 and OSM
 CNTF elisa kit  >112 publications with gp130 and CNTF
 STAT1 elisa kit  >69 publications with gp130 and STAT1
 JAK1 elisa kit  >51 publications with gp130 and JAK1
 IL6 elisa kit  >44 publications with gp130 and IL6
 SOCS3 elisa kit  >35 publications with gp130 and SOCS3
 PTPN11 elisa kit  >32 publications with gp130 and PTPN11
 IL6R elisa kit  >18 publications with gp130 and IL6R
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 Interleukin-6 Signaling Pathway antibodies  Interleukin-6 Signaling Pathway Diagram
Diseases associated with gp130 elisa kitOrgans/Tissues associated with gp130 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >113 publications with gp130 and Inflammation
 Cardiovascular Diseases Antibodies  >100 publications with gp130 and Cardiovascular Diseases
 Carcinoma Antibodies  >58 publications with gp130 and Carcinoma
 Nervous System Diseases Antibodies  >51 publications with gp130 and Nervous System Diseases
 Disease Models, Animal Antibodies  >50 publications with gp130 and Disease Models, Animal
 Heart Diseases Antibodies  >47 publications with gp130 and Heart Diseases
 Necrosis Antibodies  >43 publications with gp130 and Necrosis
 Liver Diseases Antibodies  >37 publications with gp130 and Liver Diseases
 Hypertrophy Antibodies  >30 publications with gp130 and Hypertrophy
 Arthritis, Rheumatoid Antibodies  >25 publications with gp130 and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >211 publications with gp130 and Blood
 Liver Antibodies  >86 publications with gp130 and Liver
 Bone Antibodies  >79 publications with gp130 and Bone
 Brain Antibodies  >78 publications with gp130 and Brain
 Heart Antibodies  >71 publications with gp130 and Heart
 Muscle Antibodies  >63 publications with gp130 and Muscle
 Bone Marrow Antibodies  >57 publications with gp130 and Bone Marrow
 Nerve Antibodies  >55 publications with gp130 and Nerve
 Vascular Antibodies  >33 publications with gp130 and Vascular
 Embryonic Tissue Antibodies  >33 publications with gp130 and Embryonic Tissue
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