NP_063937.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,981 Da
NCBI Official Full Name
glycogen synthase kinase-3 alpha
NCBI Official Synonym Full Names
glycogen synthase kinase 3 alpha
NCBI Protein Information
glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A
UniProt Protein Name
Glycogen synthase kinase-3 alpha
UniProt Synonym Protein Names
Serine/threonine-protein kinase GSK3A (EC:2.7.11.1)
UniProt Synonym Gene Names
UniProt Entry Name
GSK3A_HUMAN
NCBI Summary for GSK3a
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
UniProt Comments for GSK3a
GSK3A: a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase. A GSK3 promoter SNP effects progression of bipolar disorder. The GSK3 inhibitor, lithium, is used to treat bipolar disorder and is seen to block plaque formation. GSK3 generally opposes the action of insulin, and GSK3 hyperactivity is thought to contribute to insulin resistant (type II) diabetes. GSK3 also negatively regulates cardiac hypertrophy. A tumor suppressor role is indicated by the oncogenic potential of stabilized -catenin mutants that lack GSK3 phosphorylation sites. Inhibitor: AR-A014418
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.26; Protein kinase, CMGC; EC 2.7.11.1; CMGC group; GSK family; GSK subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cytosol; beta-catenin destruction complex
Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; ATP binding
Biological Process: glycogen metabolic process; proteasomal ubiquitin-dependent protein catabolic process; genetic imprinting; nerve growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; negative regulation of transferase activity; positive regulation of cAMP biosynthetic process; negative regulation of glycogen biosynthetic process; epidermal growth factor receptor signaling pathway; nervous system development; negative regulation of TOR signaling pathway; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; Wnt receptor signaling pathway; unfolded protein response; positive regulation of peptidyl-serine phosphorylation; negative regulation of glucose import; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of protein catabolic process; regulation of systemic arterial blood pressure; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of heart contraction
Research Articles on GSK3a
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