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GSK3beta elisa kit :: Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2533470
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
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 Product Name   

Glycogen Synthase Kinase 3 Beta (GSK3beta), ELISA Kit

★Popular Item★
 Also Known As   

Mouse GSK3beta (Glycogen Synthase Kinase 3 Beta) ELISA Kit

 Product Gene Name   

GSK3beta elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605004
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 Species Reactivity    Mouse
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 Specificity    This kit recognizes natural and recombinantMouseGSK3beta. No significant cross-reactivity or interference between MouseGSK3beta and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GSK3beta elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GSK3beta purchase    MBS2533470 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glycogen Synthase Kinase 3 Beta (GSK3beta) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing GSK3beta, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2533470 kit is based on GSK3beta antibody-GSK3beta antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GSK3beta antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GSK3beta. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for GSK3beta elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of MouseGSK3betaconcentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to GSK3beta. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for GSK3betaand Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain GSK3beta, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of GSK3beta.You can calculate the concentration of GSK3betain the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of GSK3beta elisa kit    GSK3beta elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2533470. Click to request current manual
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NCBI/Uniprot data below describe general gene information for GSK3beta. It may not necessarily be applicable to this product.
 NCBI GI #    5730335
 NCBI GeneID    2932
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 UniProt Secondary Accession #    Q9BWH3; Q9UL47; D3DN89 [Other Products]
 UniProt Related Accession #    P49841 [Other Products]
 Molecular Weight    48,034 Da
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 NCBI Official Full Name    glycogen synthase kinase 3 beta, partial
 NCBI Official Synonym Full Names    glycogen synthase kinase 3 beta
 NCBI Official Symbol    GSK3B [Similar Products]
 NCBI Protein Information    glycogen synthase kinase-3 beta
 UniProt Protein Name    Glycogen synthase kinase-3 beta
 UniProt Synonym Protein Names   
Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
 UniProt Gene Name    GSK3B [Similar Products]
 UniProt Synonym Gene Names    GSK-3 beta [Similar Products]
 UniProt Entry Name    GSK3B_HUMAN
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 NCBI Summary for GSK3beta    The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for GSK3beta    GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: Kinase, protein; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CMGC; CMGC group; GSK family; GSK subfamily

Chromosomal Location of Human Ortholog: 3q13.3

Cellular Component: axon; beta-catenin destruction complex; cell soma; centrosome; cytoplasm; cytosol; dendritic shaft; dendritic spine; growth cone; lipid raft; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; ribonucleoprotein complex

Molecular Function: ATP binding; beta-catenin binding; integrin binding; ionotropic glutamate receptor binding; kinase activity; NF-kappaB binding; p53 binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; ubiquitin protein ligase binding

Biological Process: aging; axon guidance; cell migration; circadian rhythm; epidermal growth factor receptor signaling pathway; epithelial to mesenchymal transition; ER overload response; establishment of cell polarity; fat cell differentiation; fibroblast growth factor receptor signaling pathway; genetic imprinting; glycogen metabolic process; hippocampus development; innate immune response; myoblast fusion; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of glycogen biosynthetic process; negative regulation of MAP kinase activity; negative regulation of neuron maturation; negative regulation of NFAT protein import into nucleus; negative regulation of nitric-oxide synthase activity; negative regulation of protein binding; negative regulation of protein complex assembly; nerve growth factor receptor signaling pathway; organ morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphoinositide-mediated signaling; positive regulation of axon extension; positive regulation of cell-matrix adhesion; positive regulation of GTPase activity; positive regulation of neuron apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein export from nucleus; re-entry into mitotic cell cycle; regulation of microtubule-based process; regulation of neuronal synaptic plasticity; response to activity; response to drug; response to estradiol stimulus; response to insulin stimulus; Wnt receptor signaling pathway through beta-catenin
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 Research Articles on GSK3beta    1. findings suggest that there exists a significant association between GSK3beta rs334558 T>C polymorphism and increased susceptibility of Alzheimers Disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GSK3beta elisa kitPathways associated with GSK3beta elisa kit
 Reference Product  PubMed Publications
 CTNNB1 elisa kit  >31 publications with GSK3beta and CTNNB1
 JUN elisa kit  >17 publications with GSK3beta and JUN
 MAPT elisa kit  >14 publications with GSK3beta and MAPT
 AKT1 elisa kit  >9 publications with GSK3beta and AKT1
 MYC elisa kit  >7 publications with GSK3beta and MYC
 APC elisa kit  >4 publications with GSK3beta and APC
 AXIN1 elisa kit  >4 publications with GSK3beta and AXIN1
 FRAT1 elisa kit  >2 publications with GSK3beta and FRAT1
 AXIN2 elisa kit  >2 publications with GSK3beta and AXIN2
 LRP6 elisa kit  >1 publications with GSK3beta and LRP6
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with GSK3beta elisa kitOrgans/Tissues associated with GSK3beta elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >32 publications with GSK3beta and Nervous System Diseases
 Brain Diseases Antibodies  >29 publications with GSK3beta and Brain Diseases
 Alzheimer Disease Antibodies  >19 publications with GSK3beta and Alzheimer Disease
 Bipolar Disorder Antibodies  >18 publications with GSK3beta and Bipolar Disorder
 Schizophrenia Antibodies  >14 publications with GSK3beta and Schizophrenia
 Disease Models, Animal Antibodies  >14 publications with GSK3beta and Disease Models, Animal
 Depressive Disorder Antibodies  >12 publications with GSK3beta and Depressive Disorder
 Cardiovascular Diseases Antibodies  >8 publications with GSK3beta and Cardiovascular Diseases
 Heart Diseases Antibodies  >6 publications with GSK3beta and Heart Diseases
 Inflammation Antibodies  >6 publications with GSK3beta and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >46 publications with GSK3beta and Brain
 Blood Antibodies  >23 publications with GSK3beta and Blood
 Muscle Antibodies  >12 publications with GSK3beta and Muscle
 Liver Antibodies  >11 publications with GSK3beta and Liver
 Ovary Antibodies  >11 publications with GSK3beta and Ovary
 Bone Antibodies  >9 publications with GSK3beta and Bone
 Heart Antibodies  >7 publications with GSK3beta and Heart
 Lung Antibodies  >6 publications with GSK3beta and Lung
 Embryonic Tissue Antibodies  >5 publications with GSK3beta and Embryonic Tissue
 Connective Tissue Antibodies  >4 publications with GSK3beta and Connective Tissue
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