NP_057906.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
65,332 Da
NCBI Official Full Name
glypican-3
NCBI Official Synonym Full Names
glypican 3
NCBI Official Synonym Symbols
NCBI Protein Information
glypican-3
UniProt Protein Name
Glypican-3
UniProt Entry Name
GPC3_MOUSE
UniProt Comments for Gpc3
GPC3: Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1); also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. Belongs to the glypican family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor
Cellular Component: anchored to plasma membrane; extracellular region; integral to plasma membrane; lysosome; membrane; plasma membrane; proteinaceous extracellular matrix
Molecular Function: heparan sulfate proteoglycan binding; protease inhibitor activity; protein binding
Biological Process: anterior/posterior axis specification; body morphogenesis; bone mineralization; embryonic hindlimb morphogenesis; kidney development; lung development; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of growth; negative regulation of peptidase activity; negative regulation of smoothened signaling pathway; organ morphogenesis; osteoclast differentiation; positive regulation of BMP signaling pathway; positive regulation of endocytosis; positive regulation of glucose import; positive regulation of protein catabolic process; positive regulation of smoothened signaling pathway; regulation of growth; ureteric bud branching
Research Articles on Gpc3
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Products associated with Gpc3 elisa kit
Pathways associated with Gpc3 elisa kit
Diseases associated with Gpc3 elisa kit
Organs/Tissues associated with Gpc3 elisa kit
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