NP_004123.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,864 Da
NCBI Official Full Name
hyaluronan-binding protein 2 isoform 1 preproprotein
NCBI Official Synonym Full Names
hyaluronan binding protein 2
NCBI Protein Information
hyaluronan-binding protein 2; factor VII activating protein; factor VII-activating protease; factor seven-activating protease; hepatocyte growth factor activator-like protein; hyaluronic acid binding protein 2; plasma hyaluronan binding protein; plasma hyaluronan-binding protein
UniProt Protein Name
Hyaluronan-binding protein 2
UniProt Synonym Protein Names
Factor VII-activating protease; Factor seven-activating protease; FSAP; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding proteinCleaved into the following 4 chains:Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form
UniProt Synonym Gene Names
UniProt Entry Name
HABP2_HUMAN
NCBI Summary for HABP
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
UniProt Comments for HABP
HABP2: Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII. Belongs to the peptidase S1 family.
Protein type: Secreted, signal peptide; EC 3.4.21.-; Motility/polarity/chemotaxis; Protease; Secreted; Cell adhesion
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: extracellular space; extracellular region
Molecular Function: glycosaminoglycan binding; serine-type endopeptidase activity
Biological Process: proteolysis; cell adhesion
Disease: Thrombophilia Due To Thrombin Defect; Thyroid Cancer, Nonmedullary, 5
Research Articles on HABP
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Diseases associated with HABP elisa kit
Organs/Tissues associated with HABP elisa kit
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