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HSPA1B elisa kit :: Mouse Heat Shock 70kDa Protein 1B (HSPA1B) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS160188 HSPA1B elisa kit
Unit / Price
48-Strip-Wells  /  $280 +1 FREE 8GB USB
96-Strip-Wells  /  $445 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,830 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,580 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat Shock 70kDa Protein 1B (HSPA1B), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Heat Shock 70kDa Protein 1B (HSPA1B) ELISA Kit

 Product Gene Name   

HSPA1B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P0DMV9
 Species Reactivity    Mouse
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 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HSPA1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HSPA1B purchase    MBS160188 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Heat Shock 70kDa Protein 1B (HSPA1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HSPA1B. The ELISA analytical biochemical technique of the MBS160188 kit is based on HSPA1B antibody-HSPA1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HSPA1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HSPA1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Sample Manual Insert of MBS160188. Click to request current manual
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NCBI/Uniprot data below describe general gene information for HSPA1B. It may not necessarily be applicable to this product.
 NCBI GI #    167466173
 NCBI GeneID    3304
 NCBI Accession #    NP_005337.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005346.4 [Other Products]
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 UniProt Primary Accession #    P0DMV9 [Other Products]
 UniProt Secondary Accession #    P08107; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0; B4E3B6 [Other Products]
 UniProt Related Accession #    P0DMV9 [Other Products]
 Molecular Weight    70,052 Da
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 NCBI Official Full Name    heat shock 70 kDa protein 1B
 NCBI Official Synonym Full Names    heat shock protein family A (Hsp70) member 1B
 NCBI Official Symbol    HSPA1B [Similar Products]
 NCBI Official Synonym Symbols   
HSP72; HSPA1; HSX70; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1B
[Similar Products]
 NCBI Protein Information    heat shock 70 kDa protein 1B
 UniProt Protein Name    Heat shock 70 kDa protein 1B
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 2; HSP70-22 PublicationsManual assertion based on opinion iniRef.3"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-499.
 Protein Family    Heat shock 70 kDa protein
 UniProt Gene Name    HSPA1B [Similar Products]
 UniProt Synonym Gene Names    HSP721 PublicationManual assertion based on opinion iniRef.36; HSP70-22 PublicationsManual assertion based on opinion iniRef.3; HSP70.2 [Similar Products]
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 NCBI Summary for HSPA1B    This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HSPA1B    Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
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 Research Articles on HSPA1B    1. Heat shock protein 70-2 (HSP70-2) expression was detected in 78 % of colorectal cancer (CRC) patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSPA1B elisa kitPathways associated with HSPA1B elisa kit
 Reference Product  PubMed Publications
 HSF1 elisa kit  >8 publications with HSPA1B and HSF1
 DNAJB1 elisa kit  >5 publications with HSPA1B and DNAJB1
 BAG3 elisa kit  >3 publications with HSPA1B and BAG3
 STIP1 elisa kit  >2 publications with HSPA1B and STIP1
 TP53 elisa kit  >2 publications with HSPA1B and TP53
 HSPBP1 elisa kit  >1 publications with HSPA1B and HSPBP1
 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with HSPA1B elisa kitOrgans/Tissues associated with HSPA1B elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with HSPA1B and Cardiovascular Diseases
 Inflammation Antibodies  >14 publications with HSPA1B and Inflammation
 Nervous System Diseases Antibodies  >13 publications with HSPA1B and Nervous System Diseases
 Necrosis Antibodies  >11 publications with HSPA1B and Necrosis
 Lung Diseases Antibodies  >8 publications with HSPA1B and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >7 publications with HSPA1B and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >7 publications with HSPA1B and Heart Diseases
 Liver Diseases Antibodies  >7 publications with HSPA1B and Liver Diseases
 Disease Models, Animal Antibodies  >6 publications with HSPA1B and Disease Models, Animal
 Liver Neoplasms Antibodies  >6 publications with HSPA1B and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with HSPA1B and Blood
 Brain Antibodies  >13 publications with HSPA1B and Brain
 Liver Antibodies  >12 publications with HSPA1B and Liver
 Kidney Antibodies  >8 publications with HSPA1B and Kidney
 Lung Antibodies  >8 publications with HSPA1B and Lung
 Muscle Antibodies  >7 publications with HSPA1B and Muscle
 Testis Antibodies  >5 publications with HSPA1B and Testis
 Stomach Antibodies  >5 publications with HSPA1B and Stomach
 Pancreas Antibodies  >4 publications with HSPA1B and Pancreas
 Heart Antibodies  >4 publications with HSPA1B and Heart
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