NP_115930.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
9,352 Da
NCBI Official Full Name
hepcidin preproprotein
NCBI Official Synonym Full Names
hepcidin antimicrobial peptide
NCBI Protein Information
hepcidin
UniProt Protein Name
Hepcidin
UniProt Synonym Gene Names
NCBI Summary for Hepc
This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]
UniProt Comments for Hepc
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
Research Articles on Hepc
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Products associated with Hepc elisa kit
Pathways associated with Hepc elisa kit
Diseases associated with Hepc elisa kit
Organs/Tissues associated with Hepc elisa kit
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