NP_001012331.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,145 Da
NCBI Official Full Name
high affinity nerve growth factor receptor isoform 1
NCBI Official Synonym Full Names
neurotrophic tyrosine kinase, receptor, type 1
NCBI Official Synonym Symbols
MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA [Similar Products]
NCBI Protein Information
high affinity nerve growth factor receptor
UniProt Protein Name
High affinity nerve growth factor receptor
UniProt Synonym Protein Names
Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA
UniProt Synonym Gene Names
UniProt Entry Name
NTRK1_HUMAN
NCBI Summary for Ntrk1
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
UniProt Comments for Ntrk1
TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.
Protein type: Protein kinase, TK; Membrane protein, integral; Oncoprotein; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Trk family
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: axon; cell soma; cell surface; cytoplasmic vesicle; dendrite; early endosome; early endosome membrane; endosome; integral to plasma membrane; late endosome; late endosome membrane; plasma membrane; protein complex; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; adenylate cyclase activation; aging; axon guidance; B cell differentiation; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; learning and/or memory; mechanoreceptor differentiation; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; olfactory nerve development; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; phospholipase C activation; positive regulation of angiogenesis; positive regulation of GTPase activity; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; Ras protein signal transduction; response to activity; response to axon injury; response to drug; response to electrical stimulus; response to ethanol; response to hydrostatic pressure; response to nutrient levels; response to radiation; Sertoli cell development; small GTPase mediated signal transduction; sympathetic nervous system development; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Insensitivity To Pain, Congenital, With Anhidrosis; Thyroid Carcinoma, Familial Medullary
Research Articles on Ntrk1
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