NP_000871.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
7,687 Da
NCBI Official Full Name
interleukin-7 isoform 1
NCBI Official Synonym Full Names
interleukin 7
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-7
UniProt Protein Name
Interleukin-7
UniProt Synonym Gene Names
UniProt Entry Name
IL7_HUMAN
NCBI Summary for IL-7
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
UniProt Comments for IL-7
IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Secreted, signal peptide; Cell cycle regulation; Cytokine; Apoptosis; Secreted
Chromosomal Location of Human Ortholog: 8q12-q13
Cellular Component: extracellular space; extracellular region
Molecular Function: interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity
Biological Process: positive regulation of organ growth; humoral immune response; organ morphogenesis; T cell lineage commitment; positive regulation of T cell differentiation; cell-cell signaling; homeostasis of number of cells within a tissue; regulation of gene expression; negative regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; bone resorption; negative regulation of apoptosis
Research Articles on IL-7
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Products associated with IL-7 elisa kit
Pathways associated with IL-7 elisa kit
Diseases associated with IL-7 elisa kit
Organs/Tissues associated with IL-7 elisa kit
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