EAW61608.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,831 Da
NCBI Official Full Name
IL2-inducible T-cell kinase
NCBI Official Synonym Full Names
IL2-inducible T-cell kinase
NCBI Protein Information
tyrosine-protein kinase ITK/TSK
UniProt Protein Name
Tyrosine-protein kinase ITK/TSK
UniProt Synonym Protein Names
Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk
UniProt Synonym Gene Names
UniProt Entry Name
ITK_HUMAN
NCBI Summary for ITK
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
UniProt Comments for ITK
ITK: an intracellular tyrosine kinase of the Tec family expressed in T-cells. The protein contains both SH2 and SH3 domains and plays a role in T-cell proliferation and differentiation. Itk-deficient murine T cells display defects in TCR/CD3-induced actin polymerization.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: 5q31-q32
Cellular Component: extrinsic to internal side of plasma membrane; intercellular junction; cytosol
Molecular Function: protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: B cell receptor signaling pathway; interleukin-4 production; adaptive immune response; T cell activation; phospholipase C activation; interferon-gamma production; cellular defense response; cytokine production; innate immune response; NK T cell differentiation; signal transduction; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
Disease: Lymphoproliferative Syndrome 1
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Products associated with ITK elisa kit
Pathways associated with ITK elisa kit
Diseases associated with ITK elisa kit
Organs/Tissues associated with ITK elisa kit
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