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IFN-alpha / betaR elisa kit :: Mouse Interferon Alpha / Beta Receptor (IFN-alpha / betaR) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS265913
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $275 +1 FREE 8GB USB
96-Strip-Wells  /  $435 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,755 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,150 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon Alpha / Beta Receptor (IFN-alpha / betaR), ELISA Kit

 Also Known As   

Mouse Interferon Alpha / Beta Receptor (IFN-alpha / betaR) ELISA Kit

 Product Synonym Names    Mouse Interferon Alpha / Beta Receptor (IFN-a / bR) ELISA Kit
 Product Gene Name   

IFN-alpha / betaR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 610424
 3D Structure    ModBase 3D Structure for P48551
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 Species Reactivity    Mouse
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 Samples    Mouse serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant IFN-alpha/betaR concentration
 Assay Type    Sandwich
 Detection Range    200 ng/ml-0.312 ng/ml
 Sensitivity    0.06 ng/ml.
 Intra-assay Precision    <= 8%
 Inter-assay Precision    <= 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IFN-alpha / betaR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IFN-alpha / betaR purchase    MBS265913 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interferon Alpha / Beta Receptor (IFN-alpha / betaR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 200 ng/ml-0.312 ng/ml in biological research samples containing IFN-alpha / betaR, with an estimated sensitivity of 0.06 ng/ml. The ELISA analytical biochemical technique of the MBS265913 kit is based on IFN-alpha / betaR antibody-IFN-alpha / betaR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFN-alpha / betaR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFN-alpha / betaR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Mouse serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant IFN-alpha/betaR concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IFN-alpha / betaR elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Mouse IFN-alpha/betaR monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of IFN-alpha / betaR elisa kit    IFN-alpha / betaR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS265913. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IFN-alpha / betaR. It may not necessarily be applicable to this product.
 NCBI GI #    1620401
 NCBI GeneID    3455
 NCBI Accession #    CAA61914.1 [Other Products]
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 UniProt Primary Accession #    P48551 [Other Products]
 UniProt Secondary Accession #    Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9 [Other Products]
 UniProt Related Accession #    P48551 [Other Products]
 Molecular Weight    27,384 Da
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 NCBI Official Full Name    interferon alpha /beta receptor
 NCBI Official Synonym Full Names    interferon (alpha, beta and omega) receptor 2
 NCBI Official Symbol    IFNAR2 [Similar Products]
 NCBI Official Synonym Symbols   
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
[Similar Products]
 NCBI Protein Information    interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain
 UniProt Protein Name    Interferon alpha/beta receptor 2
 UniProt Synonym Protein Names   
Interferon alpha binding protein; Type I interferon receptor 2
 UniProt Gene Name    IFNAR2 [Similar Products]
 UniProt Synonym Gene Names    IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2 [Similar Products]
 UniProt Entry Name    INAR2_HUMAN
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 NCBI Summary for IFN-alpha / betaR    The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFN-alpha / betaR    IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; extracellular region; plasma membrane

Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; response to virus; cytokine and chemokine mediated signaling pathway; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To
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 Research Articles on IFN-alpha / betaR    1. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFN-alpha / betaR elisa kitPathways associated with IFN-alpha / betaR elisa kit
 Reference Product  PubMed Publications
 IFNA2 elisa kit  >179 publications with IFN-alpha / betaR and IFNA2
 IFNAR1 elisa kit  >132 publications with IFN-alpha / betaR and IFNAR1
 STAT1 elisa kit  >31 publications with IFN-alpha / betaR and STAT1
 STAT2 elisa kit  >25 publications with IFN-alpha / betaR and STAT2
 JAK1 elisa kit  >23 publications with IFN-alpha / betaR and JAK1
 TYK2 elisa kit  >21 publications with IFN-alpha / betaR and TYK2
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with IFN-alpha / betaR elisa kitOrgans/Tissues associated with IFN-alpha / betaR elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >31 publications with IFN-alpha / betaR and Neoplasms
 Liver Diseases Antibodies  >25 publications with IFN-alpha / betaR and Liver Diseases
 Carcinoma Antibodies  >20 publications with IFN-alpha / betaR and Carcinoma
 Nervous System Diseases Antibodies  >16 publications with IFN-alpha / betaR and Nervous System Diseases
 Adenocarcinoma Antibodies  >14 publications with IFN-alpha / betaR and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >10 publications with IFN-alpha / betaR and Carcinoma, Hepatocellular
 Necrosis Antibodies  >8 publications with IFN-alpha / betaR and Necrosis
 Hepatitis B Antibodies  >8 publications with IFN-alpha / betaR and Hepatitis B
 Liver Neoplasms Antibodies  >7 publications with IFN-alpha / betaR and Liver Neoplasms
 Inflammation Antibodies  >7 publications with IFN-alpha / betaR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with IFN-alpha / betaR and Blood
 Liver Antibodies  >27 publications with IFN-alpha / betaR and Liver
 Lung Antibodies  >9 publications with IFN-alpha / betaR and Lung
 Bone Marrow Antibodies  >6 publications with IFN-alpha / betaR and Bone Marrow
 Kidney Antibodies  >6 publications with IFN-alpha / betaR and Kidney
 Uterus Antibodies  >6 publications with IFN-alpha / betaR and Uterus
 Brain Antibodies  >4 publications with IFN-alpha / betaR and Brain
 Spleen Antibodies  >3 publications with IFN-alpha / betaR and Spleen
 Lymph Node Antibodies  >2 publications with IFN-alpha / betaR and Lymph Node
 Intestine Antibodies  >2 publications with IFN-alpha / betaR and Intestine
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