NP_001248348.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,622 Da
NCBI Official Full Name
interleukin-1 receptor type 2 isoform 2
NCBI Official Synonym Full Names
interleukin 1 receptor, type II
NCBI Official Synonym Symbols
IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2 [Similar Products]
NCBI Protein Information
interleukin-1 receptor type 2; IL-1R-beta; antigen CDw121b; IL-1 type II receptor; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta; interleukin 1 receptor type II variant 3
UniProt Protein Name
Interleukin-1 receptor type 2
UniProt Synonym Protein Names
CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II; CD_antigen: CD121bCleaved into the following 2 chains:Interleukin-1 receptor type 2, membrane form; mIL-1R2; mIL-1RII; Interleukin-1 receptor type 2, soluble form; sIL-1R2; sIL-1RII
UniProt Synonym Gene Names
IL1RB; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII [Similar Products]
UniProt Entry Name
IL1R2_HUMAN
NCBI Summary for IL-1
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
UniProt Comments for IL-1
IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: extracellular region; plasma membrane; integral to membrane
Molecular Function: protein binding; interleukin-1, Type II, blocking receptor activity; interleukin-1 receptor activity
Biological Process: cytokine and chemokine mediated signaling pathway; immune response
Research Articles on IL-1
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Organs/Tissues associated with IL-1 elisa kit
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