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IL1RA elisa kit :: Mouse Interleukin 1 Receptor antagonist ELISA Kit

Scan QR to view Datasheet Catalog #    MBS726604
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 1 Receptor antagonist (IL1RA), ELISA Kit

 Also Known As   

Mouse Interleukin 1 Receptor antagonist ELISA Kit

 Product Gene Name   

IL1RA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    612852
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 Species Reactivity    Mouse
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Sandwich
 Detection Range    50-1000pg/mL
 Sensitivity    1.0pg/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IL1RA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IL1RA purchase    MBS726604 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin 1 Receptor antagonist (IL1RA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 50-1000pg/mL in biological research samples containing IL1RA, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS726604 kit is based on IL1RA antibody-IL1RA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL1RA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL1RA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for IL1RA elisa kit    Immunology
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 Typical Testing Data/Standard Curve (for reference only) of IL1RA elisa kit    IL1RA elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS726604. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IL1RA. It may not necessarily be applicable to this product.
 NCBI GI #    186386
 NCBI GeneID    3557
 NCBI Accession #    AAB41943.1 [Other Products]
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 UniProt Secondary Accession #    Q14628; Q53SC2; Q7RTZ4; Q96GD6; Q9UPC0; A8K4G1 [Other Products]
 UniProt Related Accession #    P18510 [Other Products]
 Molecular Weight    16,142 Da
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 NCBI Official Full Name    interleukin 1 receptor antagonist
 NCBI Official Synonym Full Names    interleukin 1 receptor antagonist
 NCBI Official Symbol    IL1RN [Similar Products]
 NCBI Official Synonym Symbols   
DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra)
 UniProt Protein Name    Interleukin-1 receptor antagonist protein
 UniProt Synonym Protein Names   
ICIL-1RA; IL1 inhibitor; INN: Anakinra
 UniProt Gene Name    IL1RN [Similar Products]
 UniProt Synonym Gene Names    IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP [Similar Products]
 UniProt Entry Name    IL1RA_HUMAN
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 NCBI Summary for IL1RA    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL1RA    IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular

Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity

Biological Process: response to drug; positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; sensory perception of pain; fever; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; response to activity; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 4; Gastric Cancer, Hereditary Diffuse; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
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 Research Articles on IL1RA    1. Patients with IL1B -31C carrier, or IL1RA 2/4 genotype carry a risk for DSS, implying that IL1B may play a role in pathogenesis of dengue shock syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL1RA elisa kitPathways associated with IL1RA elisa kit
 Reference Product  PubMed Publications
 IL1A elisa kit  >90 publications with IL1RA and IL1A
 IL4 elisa kit  >24 publications with IL1RA and IL4
 IL8 elisa kit  >23 publications with IL1RA and IL8
 IL1R1 elisa kit  >18 publications with IL1RA and IL1R1
 MMP3 elisa kit  >5 publications with IL1RA and MMP3
 IL1R2 elisa kit  >5 publications with IL1RA and IL1R2
 IL1RL2 elisa kit  >2 publications with IL1RA and IL1RL2
 SELE elisa kit  >1 publications with IL1RA and SELE
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
Diseases associated with IL1RA elisa kitOrgans/Tissues associated with IL1RA elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >773 publications with IL1RA and Necrosis
 Inflammation Antibodies  >687 publications with IL1RA and Inflammation
 Arthritis, Rheumatoid Antibodies  >301 publications with IL1RA and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >188 publications with IL1RA and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >164 publications with IL1RA and Disease Models, Animal
 Skin Diseases Antibodies  >123 publications with IL1RA and Skin Diseases
 Lung Diseases Antibodies  >109 publications with IL1RA and Lung Diseases
 Pain Antibodies  >82 publications with IL1RA and Pain
 Kidney Diseases Antibodies  >79 publications with IL1RA and Kidney Diseases
 Heart Diseases Antibodies  >74 publications with IL1RA and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1058 publications with IL1RA and Blood
 Brain Antibodies  >174 publications with IL1RA and Brain
 Skin Antibodies  >126 publications with IL1RA and Skin
 Lung Antibodies  >109 publications with IL1RA and Lung
 Liver Antibodies  >108 publications with IL1RA and Liver
 Heart Antibodies  >77 publications with IL1RA and Heart
 Stomach Antibodies  >51 publications with IL1RA and Stomach
 Spleen Antibodies  >43 publications with IL1RA and Spleen
 Intestine Antibodies  >39 publications with IL1RA and Intestine
 Eye Antibodies  >38 publications with IL1RA and Eye
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