NP_839991.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,117 Da
NCBI Official Full Name
metastasis-suppressor KiSS-1
NCBI Official Synonym Full Names
KiSS-1 metastasis-suppressor
NCBI Official Synonym Symbols
NCBI Protein Information
metastasis-suppressor KiSS-1; metastin; kisspeptin-1; 0610012C01Rik; Kiss1 metastasis-suppressor
UniProt Protein Name
Metastasis-suppressor KiSS-1
UniProt Synonym Protein Names
Kisspeptin-1Cleaved into the following 2 chains:MetastinAlternative name(s):Kisspeptin-52
UniProt Entry Name
KISS1_MOUSE
UniProt Comments for KISS1
KiSS-1: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Belongs to the KISS1 family.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide
Cellular Component: extracellular space; neuron projection; cell soma; apical plasma membrane; cytoplasm; cytosol
Molecular Function: protein binding; G-protein-coupled receptor binding; kisspeptin receptor binding
Biological Process: positive regulation of growth hormone secretion; generation of ovulation cycle rhythm; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; negative regulation of cell migration; positive regulation of synaptic transmission; positive regulation of luteinizing hormone secretion
Research Articles on KISS1
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Pathways associated with KISS1 elisa kit
Diseases associated with KISS1 elisa kit
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